Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GIST has been shown to over-express c-KIT (CD117), the receptor tyrosine kinase. Imatinib (STI571 or Glivec) is a new type of tyrosine kinase inhibitor that selectively inhibits various tyrosine kinases and has been successfully used to treat GIST. In this study we have...

Executive Board, AAP mor appearance in young women. New Eng. J. Med., 284:878, 1971. 2. Greenwald, P., Barlow, J. J., Nasca, P. C., and Burnett, W. S. : Vaginal cancer after maternal treatment with synthetic estrogens. New Eng. J. Med., 285:390, 1971. 3. Herbst, A. L., Ulfelder, H., and Poskanzer, D. C.: Registry of clear-cell carcinoma of genital tract in young women. New Eng. J. Med., 285:407...

Glial fibrillary acidic (GFA) protein, a protein originally isolated from fibrous neuroglia (Eng et aI., 1971) and subsequently localized by specific immunofluorescence to fibrillary astrocytes (Bignami et ai, 1972; Bignami and Dahl, 1974; Uyeda et aI., 1972), is currently being used as an antigenic marker for the investigation of normal, developing and pathologically altered supporting cells o...

Because psychological aspects often are underscored in the generation of tinnitus, we assessed the neuropsychological status in our group of patients. We found an increased number of abnormal electronystagmography (ENG) recordings in tinnitus patients. The aim of this study was to compare the ENG outcome with the patients' neuropsychological status. We carried out the study on 69 subjects compl...

Background The use of biomarkers for diagnosis of Preeclampsia (PE), a life-threatening pregnancy disorder, could reduce serious complications of this disease. In this study, we investigated dysregulation of endoglin (Eng) expression and diagnostic accuracy of soluble endoglin (sEng) in PE patients. Methods For this case-control study, 26 mild and 15 severe preeclamptic women along with 20 no...

To identify mutations that cause hereditary hemorrhagic telangiectasia (HHT, or Rendu-Osler-Weber syndrome), clinical evaluations and genetic studies were performed on 32 families. Linkage studies in four of eight families indicated an endoglin (ENG) gene mutation. ENG sequences of affected members of the four linked families and probands from the 24 small families were screened for mutations, ...