Previous research in this laboratory demonstrated elevated plasma corticosterone and reduced protein kinase C (PKC) activity and selective isoform expression in the epidermis of dietary energy-restricted mice. Because PKC is implicated in skin carcinogenesis and because both energy restriction and glucocorticoid hormone inhibit skin carcinogenesis, the purpose of the present research was to det...

BACKGROUND & AIMS Low glycemic index (GI) based diets could influence the accompanying physiological adaptations to energy restriction in the treatment of obesity. It was aimed to investigate the effects of two energy-restricted diets with different food distribution and GI values on weight loss and energy metabolism in the nutritional treatment of obesity. SUBJECTS AND METHODS Participants (...

INTRODUCTION Surgery-induced oxidative stress increases the risk of perioperative complications and delay in postoperative recovery. In mice, short-term preoperative dietary and protein restriction protect against oxidative stress. We investigated the feasibility of a calorie- and protein-restricted diet in two patient populations. METHODS In this pilot study, 30 live kidney donors and 38 mor...

It has become commonplace for Randomized Controlled Trials (RCTs) to be analyzed according to Intention-to-Treat (ITT) principles in which data from all subjects are used regardless of the subjects' adherence to protocol. While ITT analyses can provide useful information in some cases, they do not answer the question that motivates many RCTs, namely, whether the treatments differ in efficacy. I...

BACKGROUND AND OBJECTIVES Obesity has become a public health problem and is a cause of some preventable illnesses. Among several methods for treating obesity, the use of food supplements is highly common. A commonly used food supplement is green coffee bean extract. The objective of this study was to evaluate the efficacy of green coffee bean extract combined with an energy-restricted diet on t...

OBJECTIVE To examine whether adherence to the Mediterranean diet was associated with longer telomere length, a biomarker of aging. DESIGN Population based cohort study. SETTING Nurses' Health Study, an ongoing prospective cohort study of 121,700 nurses enrolled in 1976; in 1989-90 a subset of 32,825 women provided blood samples. PARTICIPANTS 4676 disease-free women from nested case-contro...

Prenatal undernutrition impairs copulatory behavior and increases the tendency to become obese/overweight, which also reduces sexual behavior. Re-feeding rats prenatally undernourished with a normocaloric diet can restore their physiological conditions and copulatory behavior. Thus, the present study investigated whether a hypercaloric diet that is administered in rats during the juvenile perio...

1. A group of rats were given ad lib. a diet with a protein-energy: total energy (P: E) value of 0.03. Other animals received the same protein intake (g/kg body-weight per d) as this group, but had their energy consumption reduced lo either 90, 80. 70, 60 or SO% of the ad lib. value. 2. The restricted growth rate of rats fed on the P:E -0.03 diet ad lib. has been shown to be due entirely to the...

1. A group of rats were given ad lib, a diet with a protein-energy: total energy (P:E) value of 0 . 03. Other animals received the same protein intake (g/kg body-weight per d) as this group, but had their energy consumption reduced to either 90, 80, 70, 60 or 50% of the ad lib. value. 2. The restricted growth rate of rats fed on the P:E--0 . 03 diet ad lib. has been shown to be due entirely to ...