Cell adhesion controls various embryonic morphogenetic processes, including the development of the enteric nervous system (ENS). Ablation of β1-integrin (β1-/-) expression in enteric neural crest cells (ENCC) in mice leads to major alterations in the ENS structure caused by reduced migration and increased aggregation properties of ENCC during gut colonization, which gives rise to a Hirschsprung...

Epidermal nuclear staining occurs as a result of anti-nuclear antibody (ANA) deposition in the nucleus of keratinocyte (‘In vivo ANA’). The frequency with which it occurs in various CTD’s varies between 2.6-9.8%.[2] The high prevalence in our study could be due to the smaller study sample. Four different patterns of ENS (viz. speckled, homogenous, nucleolar and rim) have been reported in the li...

BACKGROUND Ca(2+)/calmodulin-dependent protein kinases (CaMKs) are major downstream mediators of neuronal calcium signaling that regulate multiple neuronal functions. CaMKII, one of the key CaMKs, plays a significant role in mediating cellular responses to external signaling molecules. Although calcium signaling plays an essential role in the enteric nervous system (ENS), the role of CaMKII in ...

The avian enteric nervous system (ENS) consists of a vast number of unusually small ganglia compared to other peripheral ganglia. Each ENS ganglion at mid-gestation has a core of neurons and a shell of mesenchymal precursor/glia-like enteric neural crest (ENC) cells. To study ENS cell ganglionation we isolated midgut ENS cells by HNK-1 fluorescence-activated cell sorting (FACS) from E5 and E8 q...

in this context, a novel structure has been proposed for simple differential evolutionary (de) algorithm to solve optimal recloser placement. for this, an operator is added to de algorithm to adapt concept of the problem. other contribution of this work is formulating a novel objective function. the proposed objective function has been formulated to improve four reliability indices which consis...

BACKGROUND Reliable methods of labeling human enteric nervous system (ENS) stem cells for use in novel cell replacement therapies for enteric neuropathies are lacking. Here, we explore the possibility of using lentiviral vectors expressing fluorescent reporter genes to transduce, label, and trace mouse and human ENS stem cells following transplantation into mouse gut. METHODS Enteric nervous ...

In the present study, Cd(2+) adsorption on polyacrylate-coated TiO(2) engineered nanoparticles (TiO(2)-ENs) and its effect on the bioavailability as well as toxicity of Cd(2+) to a green alga Chlamydomonas reinhardtii were investigated. TiO(2)-ENs could be well dispersed in the experimental medium and their pH(pzc) is approximately 2. There was a quick adsorption of Cd(2+) on TiO(2)-ENs and a s...

abstract aim: to assess anti-neuronal antibodies (na) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (cd) patients. background: neurological manifestations are estimated to occur in about 10% of celiac disease patients and na to central nervous system (cns) and enteric nervous system (ens) are found in a significant proportion of them. little is ...

Ret signaling is critical for formation of the enteric nervous system (ENS) because Ret activation promotes ENS precursor survival, proliferation, and migration and provides trophic support for mature enteric neurons. Although these roles are well established, we now provide evidence that increasing levels of the Ret ligand glial cell line-derived neurotrophic factor (GDNF) in mice causes alter...