Although the majority of known vacuolar proteins transit through the secretory pathway, two vacuole-resident proteins have been identified that reach this organelle by an alternate pathway. These polypeptides are targeted to the vacuole directly from the cytoplasm by a novel import mechanism. The best characterized protein that uses this pathway is aminopeptidase I (API). API is synthesized as ...

Renewable energy sources help in decreasing negative environmental impacts and reducing energy-import dependency. Among all renewable segments, photovoltaic panel (PV) installations are one of the fastest-growing. Growing concern about climate change, as well public policies promoting development PV installations, have changed consumers’ behaviors attitudes. This study uses theory consumption v...

A central pathway in synaptic plasticity couples N-Methyl-D-Aspartate-receptor (NMDAR)-signaling to the activation of extracellular signal-regulated kinases (ERKs) cascade. ERK-dependency has been demonstrated for several forms of synaptic plasticity as well as learning and memory and includes local synaptic processes but also long-distance signaling to the nucleus. It is, however, controversia...

Objective: We discuss the role of diversification on dependency and security of energy supply. A system dynamics model with especial focus on the role of renewable energy resources (as a portfolio) on Finland’s energy dependency is developed. The purpose is also to cover a part of research gap exists in the system dynamics modeling of energy security investigations. Methods: A causal loops diag...

In eukaryotic evolution, the earliest branch of organisms to have mitochondria are the trypanosomatids. Their mitochondrial biogenesis not only includes import of most proteins, but also, unlike in other organisms, import of the whole set of tRNAs. In order to investigate these processes, we devised novel procedures for the isolation of mitochondria from two trypanosomatid species: Trypanosoma ...

The binary values processed and stored at the intermediary stages of an algorithm are often highly correlated. Motivated in part by this observation and the ever-increasing challenge of power density for Integrated Circuit (IC) systems, a novel reconfigurable memory framework is proposed in this thesis which builds upon traditional low power techniques such as voltage scaling in order to achiev...

Customers energy consumption pattern affects directly the grid burden, especially during peak hours. In recent years, many different control methods have been proposed to shift off-peak hours through demand response (DR) management. order effective DR management, optimization has a key role. Thus, increasing benefits for customers and encouraging them consider new controlling approaches in thei...

Protein import into the nucleus and export from the nucleus are signal-mediated processes that require energy. The nuclear transport process about which the most information is currently available is classical nuclear localization signal (NLS)-mediated nuclear import. However, details concerning the signal-mediated export of proteins and RNAs as well as alternative nuclear import pathways are b...

This paper provides a coherent review of district heating in Denmark, exploring past, present and future perspectives. Danish is known as unique internationally terms heat planning strategies, technical solutions combinations, energy efficiency sustainability, ownership models financing, it has captured the attention communities stakeholders worldwide from early days. Historically, ban on landf...

Nuclear import of classical nuclear localization sequence-containing proteins involves the assembly of an import complex at the cytoplasmic face of the nuclear pore complex (NPC) followed by movement of this complex through the NPC and release of the import substrate into the nuclear interior. This process has historically been thought to require nucleotide hydrolysis as a source of energy. We ...