Background: Mitochondrial biomarkers have been investigated in different critical settings, including ST-elevation myocardial infarction (STEMI). Whether they provide prognostic information STEMI, complementary to troponins, has not fully elucidated. We prospectively explored the in-hospital and long-term implications of cytochrome c cell-free mitochondrial DNA (mtDNA) STEMI patients undergoing...

This paper proposes a framework to support appropriate application of endpoints in animal experiments. It is recommended that unpredicted endpoints should be explicitly considered alongside scientific endpoints and justifiable endpoints as the three types of endpoint which comprise the "humane." We suggest there is a need for clear identification of each type of endpoint and an understanding of...

This paper will examine an approach for automatically identifying endpoint (the completion in etch of a thin film) during plasma etching of low open area wafers. Since many endpointing techniques use a few manually selected wavelengths or simply time the etch, the resulting endpoint detection determination may only be valid for a very short number of runs before process drift and noise render t...

Objective: To study the blood pressure, lipid and glycemic effects and safety of Vaccinium arctostaphylos leaf in the hypertensive hyperlipidemic type 2 diabetic patients. Materials and Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoin...

OBJECTIVE Endpoints used for the evaluation of immunogenicity in vaccine trials are often the proportion of individuals with immune response or geometric means of antibody concentrations for each serotype. When a vaccine includes several types of the same species, we illustrate how an endpoint combining all responses may improve clinical relevance and statistical power. STUDY DESIGN AND SETTI...