نتایج جستجو برای: endothelin a receptor

تعداد نتایج: 13599043  

Journal: :Clinical science 2002
Kazuhiro Takahashi Kazuhito Totsune Tomomi Kitamuro Masahiko Sone Osamu Murakami Shigeki Shibahara

Evidence has accumulated showing that vasoactive peptides, such as endothelin-1, adrenomedullin and urotensin-II, are expressed in various kinds of tumour cells. In the present study, the expression of endothelin-1 and endothelin receptors was studied in eight human tumour cell lines: T98G (glioblastoma), IMR-32 and NB69 (neuroblastoma), BeWo (choriocarcinoma), SW-13 (adrenocortical carcinoma),...

Journal: :European journal of medical research 2008
S Heiden T Pfab K von Websky N Vignon-Zellweger M Godes K Relle P Kalk F Theuring W Zidek Berthold Hocher

The endothelin system has been implicated in the pathogenesis of acute liver failure. However, it has not yet been assessed in a tissue specific manner. - Acute liver failure was induced in rats by two intraperitoneal injections of galactosamine (1.3 g/kg, interval of 12 hours, n = 20). The animals were sacrificed after 48 hours. - Plasma measurements demonstrated that animals receiving galacto...

Journal: :Hypertension 1993
N Momose K Fukuo S Morimoto T Ogihara

Incubation with captopril, an angiotensin I converting enzyme inhibitor, for 24 hours at concentrations up to 10(-7) M inhibited endothelin-1 secretion by endothelial cells. This inhibition of endothelin-1 secretion was reversed by coincubation with 3 x 10(-3) M NG-nitro-L-arginine, an inhibitor of nitric oxide synthesis. Furthermore, captopril enhanced the production of nitric oxide in endothe...

Journal: :Hypertension 2009
Daisuke Nakano David M Pollock

Renal medullary endothelin B receptors contribute to blood pressure regulation by facilitating salt excretion. Premenopausal females have relatively less hypertension than males; therefore, we examined whether there is a sex difference in the natriuretic response to renal medullary infusion of endothelin peptides in the rat. All of the experiments were conducted in anesthetized wild-type (wt) o...

Journal: :Basic & clinical pharmacology & toxicology 2005
Sven E Andersson Marie-Louise Edvinsson Kjell Alving Lars Edvinsson

The heart failure syndrome is associated with a reduced vasodilatory capacity in cutaneous microvessels. The aim of this study was to investigate the hypothesis that an altered activity of the endothelin system contributes to this reduction. The skin blood flow was recorded by laser Doppler flowmetry in patients with congestive heart failure and in age- and gender-matched controls without clini...

Journal: :Basic & clinical pharmacology & toxicology 2004
Bengt W Granström Cang-Bao Xu Elisabet Nilsson Ursula Hultkvist Bengtsson Lars Edvinsson

The hypothesis that up-regulation of bronchial constrictor endothelin receptors in airway smooth muscle cells may contribute to hyperreactivity during airway inflammation was tested in the present study by quantitative endothelin receptor mRNA analysis and functional responses in ring segments of rat trachea and bronchi. Real time reverse transcription polymerase chain reaction was used to quan...

Journal: :The Journal of pharmacology and experimental therapeutics 2004
Ying Xia Morris Karmazyn

Various Gq protein-coupled receptor agonists such as the alpha1 adrenoceptor agonist phenylephrine, angiotensin II, and endothelin-1 are potent hypertrophic factors. There is evidence of potential cross talk between these agents, particularly in terms of endothelin-1 as playing a central role in mediating the actions of other hypertrophic factors. Using cultured rat neonatal ventricular myocyte...

Journal: :Japanese journal of pharmacology 1996
K Goto H Hama Y Kasuya

Since the discovery of the most potent vasoconstrictor peptide, endothelin, in 1988, explosive investigations have rapidly clarified much of the basic pharmacological, biochemical and molecular biological features of endothelin, including the presence and structure of isopeptides and their genes (endothelin-1, -2 and -3), regulation of gene expression, intracellular processing, specific endothe...

Journal: :Hypertension 2012
Faquan Liang Suya Yang Lina Yao Luiz Belardinelli John Shryock

Endothelin receptor antagonists and phosphodiesterase type 5 inhibitors are used to treat pulmonary arterial hypertension. We tested the hypothesis that a selective endothelin type A receptor antagonist (ambrisentan) and a phosphodiesterase type 5 inhibitor (tadalafil) may act synergistically to relax endothelin-constricted pulmonary arteries. Rat isolated intrapulmonary arterial rings contract...

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