Objective: Aging is associated with endothelial dysfunction and arthrosclerosis. This study aimed to assesses the impact of combined circular training (resistance-interval) on endothelial-derived microparticles (EMPs) as a marker of endothelial function and cardiovascular risk factors in overweight elderly men. Materials and Methods: In this experimental study, twenty four overweight men aged ...

Endothelial activation and dysfunction play a key role in the pathogenesis of sepsis. During septic shock, endothelial dysfunction is involved in microcirculation impairment and organ dysfunction. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have several potentially important effects on endothelial function and are implicated in physiological regulation and disease pathophy...

Common vascular disease states including diabetes, hypertension and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Loss of the vasculoprotective effects of NO contributes to disease progression, but the mechanisms underlying endothelial dysfunction remain unclear. Increased superoxide production in animal models of vascula...