نتایج جستجو برای: endostatin

تعداد نتایج: 1047  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Li Ma Rafael Perini Webb McKnight Michael Dicay Andre Klein Morley D Hollenberg John L Wallace

The roles of proteinase-activated receptors (PARs) in platelet functions other than aggregation are not well understood. Among these is the release of factors that regulate the process of angiogenesis, such as endostatin and VEGF, which, respectively, inhibit and promote angiogenesis. PAR1 and PAR4 are expressed on the surface of human platelets and can be activated by thrombin. In the present ...

2013
Hao Chen Li-Xia Xue He-Li Cao Shi-Wen Chen Yan Guo Wen-Wei Gao Shi-Ming Ju Heng-Li Tian

Recent studies have suggested that endogenous angiogenesis inhibitor endostatin/collagen XVIII might play an important role in the secondary brain injury following traumatic brain injury (TBI). In this study, we measured endostatin/collagen XVIII concentrations serially for 1 week after hospitalization by using the enzyme-linked immunosorbent assay method in the cerebrospinal fluid (CSF) of 30 ...

2017
Yong-Chun Zhang Xiu-Mei Li Zhuang Yu Xiao-Li Shi Yong Li Wan-Lin Wang

Hypoxia occurs in a wide range of solid tumors, and is strongly associated with radio-resistance of malignant tumors. The aim of the present study was to investigate the effect of endostatin combined with ionizing radiation (IR) on hypoxic conditions. A total of 24 mice bearing SKOV3 ovarian carcinoma were divided into three groups. Following injection with pEgr-1-endostatin plasmid for 12 h, t...

Journal: :Acta biochimica et biophysica Sinica 2007
Huaining Teng Ying Zhang Wei Wang Xiaojun Ma Jian Fei

Endostatin, a C-terminal fragment of collagen 18a, inhibits the growth of established tumors and metastases in vivo by inhibiting angiogenesis. However, the purification procedures required for large-scale production and the attendant cost of these processes, together with the low effectiveness in clinical tests, suggest that alternative delivery methods might be required for efficient therapeu...

Journal: :American journal of nephrology 2012
Jing Chen L Lee Hamm Myra A Kleinpeter Fred Husserl Islam Enver Khan Chung-Shiuan Chen Yanxi Liu Katherine T Mills Chuan He Nader Rifai Eric E Simon Jiang He

BACKGROUND/AIMS Angiogenesis may play an important role in the renal repair process after injury. We investigated the association between plasma endostatin, an endothelial-specific antiangiogenic factor, and chronic kidney disease (CKD). METHODS We compared plasma endostatin levels in 201 CKD patients and 201 controls. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/...

Journal: :Cancer research 2001
I Ding J Z Sun B Fenton W M Liu P Kimsely P Okunieff W Min

Endostatin, a fragment of the COOH-terminal domain of mouse collagen XVIII is a recently demonstrated endogenous inhibitor of tumor angiogenesis and endothelial cell growth. Antiangiogenic therapy with endostatin in animals requires multiple and prolonged administration of the protein. Gene therapy could provide an alternative approach to continuous local delivery of this antiangiogenic factor ...

Journal: :Molecular cancer therapeutics 2004
Deborah Citrin Andrew K Lee Tamalee Scott Mary Sproull Cynthia Ménard Philip J Tofilon Kevin Camphausen

Endostatin is a potent inhibitor of angiogenesis currently in phase I clinical trials. Imaging technologies that use near-infrared fluorescent probes are well suited to the laboratory setting. The goal of this study was to determine whether endostatin labeled with a near-infrared probe (Cy5.5) could be detected in an animal and whether it would selectively localize to a tumor. Endostatin was co...

2015
Silje Reiseter Øyvind Molberg Ragnar Gunnarsson May Brit Lund Trond Mogens Aalokken Pål Aukrust Thor Ueland Torhild Garen Cathrine Brunborg Annika Michelsen Aurelija Abraityte Anna-Maria Hoffmann-Vold

INTRODUCTION Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselected cohorts of SSc and MCTD. METHODS Sera of SSc patients (N = 298) and MCTD ...

Journal: :Cancer research 2004
Anna-Karin Olsson Irja Johansson Helena Akerud Barbro Einarsson Rolf Christofferson Takako Sasaki Rupert Timpl Lena Claesson-Welsh

Endostatin constitutes the COOH-terminal 20,000 Da proteolytic fragment of collagen XVIII and has been shown to possess antiangiogenic and antitumorigenic properties. In the present study, we have investigated the role of the heparin-binding sites in the in vivo mechanism of action of endostatin. The majority of the heparin binding is mediated by arginines 155/158/184/270 in endostatin, but the...

Journal: :Tissue engineering. Part A 2010
Lily Jeng Bjorn R Olsen Myron Spector

Although there is widespread recognition of the importance of angiogenesis in tissue repair, there is little work on the inhibition of angiogenesis in the context of tissue engineering of naturally avascular tissues, like articular cartilage. The objective was to engineer a collagen-scaffold-based cartilaginous construct overexpressing a potent antiangiogenic factor, endostatin, using nonviral ...

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