AIM To confirm the hypothesis of the presence of a possible endometriosis inducing factor(s) (EIF) in the blood of women with endometriosis. PATIENTS AND METHODS Forty infertile women were studied. The study group compromised of fifteen women of each three different degrees of endometriosis and fifteen women without endometriosis as a control group. Stem cells are characterized by being spind...

We previously isolated side-population (SP) cells from a human endometrial cancer cell line, Hec1, and determined that Hec1-SP cells have cancer stem-like cell features. In this study, we isolated SP cells and non-SP (NSP) cells derived from a rat endometrial cell line expressing human [(12)Val] KRAS (RK12V cells) and determined the SP phenotype. RK12V-SP cells showed self-renewal capacity, the...

We previously isolated side-population (SP) cells from a human endometrial cancer cell line, Hec1, and determined that Hec1-SP cells have cancer stem–like cell features. In this study, we isolated SP cells and nonSP (NSP) cells derived from a rat endometrial cell line expressing human [Val] KRAS (RK12V cells) and determined the SP phenotype. RK12V-SP cells showed self-renewal capacity, the pote...

Stem cell transplantation, which is based on the application of mesenchymal stem/stromal cells (MSCs), is a rapidly developing approach to the regenerative therapy of various degenerative disorders characterized by brain and heart failure, as well as skin lesions. In comparison, the use of stem cell transplantations to treat infertility has received less attention. One of the causes of miscarri...

background: objective: the stem cell theory in the endometriosis began the advanced avenue of targeting these cells as the novel therapy to eliminate endometriosis. in this regards, studies showed that lovastatin alters the cells from a stem-like state to a more differentiated condition and reduces the stemness. the aim of this study was to investigate whether lovastatin treatment could influen...

ObjectiveTo study the effect of human plasma from different sources, namely, umbilical cord blood and adult platelet-rich (PRP), on regeneration endometrial damage.DesignComposition analysis, in vitro approaches, a preclinical murine model using to promote regeneration.SettingHospital university laboratories.Patient(s)/Animal(s)Adult four Asherman syndrome/endometrial atrophy patients one ferti...

BACKGROUND Due to increasing clinical demand for adipose tissue, a suitable cell for reconstructive adipose tissue constructs is needed. In this study, we investigated the ability of Human Endometrial-derived stem cells (EnSCs) as a new source of mesenchymal stem cells to differentiate into adipocytes. EnSCs are the abundant and easy available source with no immunological response, for cell rep...

The importance of extra cellular matrix (ECM) in development and function of different cells has been reported but little is known about its role in human endometrial epithelial cells. The aim of the present study was to examine effects of artificial ECM (Matrigel) and progesterone on the function and morphology of human endometrial epithelial cells in vitro. Methods: Endometrial samples were ...

background: during the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. however, there is a potential concern for malignant transformation after stem cell therapy. the aim of this study was to evaluate the development of hepatocellular carcinoma (hcc) after autologous bone marrow stem cell transplantation for liver cirrhosis. methods: all the patien...

The endometrium is central to mammalian fertility. The endometrial stromal cells are very dynamic, growing and differentiating throughout the estrous cycle and pregnancy. In humans, stromal cells appear to have progenitor or stem cell capabilities and the cells can even differentiate into bone. It is not clear whether bovine endometrial stromal cells exhibit a similar phenotypic plasticity. So,...