Aims Mitochondrial diseases are a heterogeneous group of genetic disorders that result from dysfunction of the respiratory chain. The endocrine disorders such as diabetes mellitus, hypoparathyroidism, hypothyroidism and growth hormone deficiency have been described in patients with mitochondrial DNA mutations. Among these, patients with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stro...

Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Groton, CT (H.E., R.S., T.S.M.) and Cambridge, MA (A.S.K.) Cardiovascular, Metabolic and Endocrine Diseases Medicinal Chemistry, Cambridge, MA (D.J.E., B.D.S., D.A.G., W.M.N., D.A.P.) and Groton (C.L.) Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA (J.P.F., X.L., M.J.) Pfizer, Inc. DMD Fast Forward. ...

The prevalence of non-communicable diseases, which insulin resistance is a major constituent, among the pediatric population exponentially increasing worldwide; this causing significant health burden, making understanding basis phenomenon an issue primary importance. During last decades, we also observed that exposure to endocrine-disrupting chemicals becoming more and common; has led researche...

endocrinologists contribute to the care of sizable populations with diabetes, thyroid disorders, obesity, metabolic syndrome, osteoporosis, dyslipidemia, pituitary disease, adrenal disease, male and female reproductive disorders and menopausal women. in addition, the trend of prevalences of endocrine and metabolic disorders show that these diseases are highly prevalent, with none becoming less ...

Autoimmune polyglandular syndrome type 2 is defined as the occurrence of Addison's disease concomitantly with autoimmune thyroid disease and/or type 1 diabetes mellitus. An 11-year-old boy with Hashimoto's disease, Addison's disease, celiac disease and Langerhans islet cell autoimmunity is described in this case report. Treatment of an endocrine disease may also trigger the onset of another end...

Nepal has a high prevalence of various endocrine diseases, which is a challenge for its endocrinologists. This article reviews the unique features and trends of endocrine disease, including diabetes, in Nepal. It focuses on the challenges and solutions that endocrine care providers face in the country.

Multiglandular endocrine neoplasia syndromes are disorders characterized by autosomal dominant inheritance patterns and by the striking patterns of clinical presentation of these endocrine tumors, which are often hormonally active. Not every patient with adenomas of more than one endocrine gland has one of these classical familial syndromes. This paper will deal with the specific diseases known...

Autophagy is an important cellular process involving the degradation of intracellular components. Its regulation is complex and while there are many methods available, there is currently no single effective way of detecting and monitoring autophagy. It has several cellular functions that are conserved throughout the body, as well as a variety of different physiological roles depending on the co...