BACKGROUND AND AIM Hepatic encephalopathy continues to be a major clinical problem and the current decade has not witnessed major therapeutic breakthroughs in this area. L-ornithine-l-aspartate (LOLA) is not frequently used as there are still some reservations about its benefits. The present study aimed to assess the effectiveness and safety of LOLA in the management of hepatic encephalopathy. ...

Objectives-To establish better operational criteria for the diagnosis of Wernicke's encephalopathy. Current criteria for diagnosing Wernicke's encephalopathy require the presence of three clinical signs (oculomotor abnormalities, cerebellar dysfunction, and an altered mental state), although it has often been reported that most patients do not filfil all these criteria. Methods-The clinical his...

BACKGROUND Hepatic encephalopathy is a chronically debilitating complication of hepatic cirrhosis. The efficacy of rifaximin, a minimally absorbed antibiotic, is well documented in the treatment of acute hepatic encephalopathy, but its efficacy for prevention of the disease has not been established. METHODS In this randomized, double-blind, placebo-controlled trial, we randomly assigned 299 p...

Wernicke encephalopathy is an acute encephalopathy, characterized by the triad of mental confusion, ophthalmoplegia, and gait ataxia. Many reasons have been reported in etiology that may be related to insufficient intake or malabsorption thiamine. Here, we present a case Wernicke's developed after gastric bypass surgery, whose diagnosis was delayed because there no feature other than papillary ...

To determine the involvement of oxidative stress in the pathogenesis of acute encephalopathy associated with human herpesvirus-6 (HHV-6) infection, we measured the levels of oxidative stress markers 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL), tau protein, and cytokines in cerebrospinal fluid (CSF) obtained from patients with HHV-6-associated acute encephalopathy (HHV-...

Hepatic encephalopathy is a challenging complication in patients with advanced liver disease. It can be defined as a neuropsychiatric syndrome caused by portosystemic venous shunting, ranging from minimal to overt hepatic encephalopathy or coma. Its pathophysiology is still unclear, although increased levels of ammonia play a key role. Diagnosis of hepatic encephalopathy is currently based on s...

More than 83,000,000 individuals have encountered Covid-19 disease, caused by novel severe acute respiratory syndrome - Coronavirus-2 (SARS-CoV-2). Besides systemic and symptoms, neurologic involvement has begun to be discussed recently. As involvement, only a few meningoencephalitis encephalopathy cases were reported in the literature. We herein present 65-year-old male patient with signs of h...

Introduction there are one million deaths from asphyxia in newborn annually. Management of this newborn is only supportive. Autologuse stem cell therapy may reduce mortality and long term morbidity. Outcome of asphyxiated newborn is related to damage CNS cells. Stem cells prevent Apoptosis and induce repairmen of injured neurons. Methods in a review study all article related to three keyword...

Posterior reversible encephalopathy syndrome (PRES) is a neurological disorder characterized by its reversibility both radiologically and clinically, it typically has favorable prognosis. Its etiopathogenesis not clear, although known that involves endothelial dysfunction of the posterior cerebral vasculature, leading to failed autoregulation. We report patient with PRES may have been caused an...

Visual evoked potential recordings were examined in 45 liver cirrhosis patients with (n = 29) and without (n = 16) encephalopathy, in 15 normal volunteers, and in one patient with an opioid induced stupor state. Visual evoked potential parameters were classified on the basis of EEG recordings. Plasma concentrations of amino acids, octopamine, and ammonia were assayed in order to document the me...