Acetalated Dextran: A Spoonful of Sugar Helps the Medicine (and Vaccine) Go Down The Ainslie Lab strives to enhance the delivery of drugs and vaccines through the application of biomaterials. To this end we apply the novel polymer Acetalated Dextran (Ac-DEX). AcDEX nano/microparticles are ideal for targeting phagocytic cells and can activate gateway immune cells, like dendritic cells or macroph...

Monodisperse multifunctional MnFe2O4/dye/silica core/shell nanoparticles have been designed and developed. The magnetic cores act as nano-heaters in biological systems under RF field excitation and the encapsulated dyes work as local temperature probes. The silica shells enable the water-solubility and biocompatibility of the NPs and protect the encapsulated fluorophores from photobleaching.

INTRODUCTION: Previously, we described the fabrication of PLGA encapsulated iron oxide nanoand microparticles (Nkansah, et al, ISMRM 2010). These particles are important advancements for molecular and cellular MRI for a number of reasons. First, they incorporate large amounts of iron, especially relative to dextran coated (U)SPIO. Secondly, PLGA has favorable degradation characteristics, with p...

Correction for ‘Acetalated dextran based nano- and microparticles: synthesis, fabrication, therapeutic applications’ by Shiqi Wang et al., Chem. Commun., 2021, DOI: 10.1039/d1cc00811k.

Introduction. Ivermectin is an antiparasitic drug that has been widely used in veterinary medicine. Parasitic diseases of farm animals cause great economic damage and pose the risk human infection. Prolonged dosage forms ivermectin are effective against them. The first step creation such a was preparation study polymeric microparticles polycaprolactone with encapsulated ivermectin. Aim. Obtaini...

Nano-sized toroidal copper(II)-hydroxide/pyrazolate assemblies, lined by H-bond donors on the inside and hydrophobic on the outside, selectively extract sulfate from mixtures with nitrate or perchlorate. Tetrabutylammonium "lids" seal the "nano-jars" and render the encapsulated sulfate anion completely buried and inaccessible, so that it is not precipitated by Ba(2+) ions.

Microparticles containing substantial amounts of radiocesium collected from the ground in Fukushima were investigated mainly by transmission electron microscopy (TEM) and X-ray microanalysis with scanning TEM (STEM). Particles of around 2 μm in diameter are basically silicate glass containing Fe and Zn as transition metals, Cs, Rb and K as alkali ions, and Sn as substantial elements. These elem...