Kinetic modeling using nonlinear differential equations is proposed to analyze the spontaneous generation of enantiomeric excess in the autocatalytic addition of diisopropylzinc to prochiral pyrimidine carbaldehydes (Soai reaction). Our approach reproduces experimentally observed giant chiral amplification from an initial enantiomeric excess of <10(-6)% to >60%, high sensitivity and positive re...

The pharmacopoeias generally apply the determination of the specific optical rotation for the characterisation of the optical purity of drugs administered as the pure enantiomer. The measurements are prescribed at D-line of sodium (589.3 nm) or rarely at some wavelenghts in the visible region of the mercury lamp (365,405,436, 546, 578 nm) and the value of the specific optical rotation should fa...

In this paper, we report the enantioselective formation of a dynamic noncovalent double rosette assembly 1a(3).(CYA)(6) composed of three 2-pyridylcalix[4]arene dimelamines (1a) and six butylcyanuric acid molecules (BuCYA). The six 2-pyridyl functionalities of the assembly interact stereoselectively with chiral dicarboxylic acids 3a-e via two-point hydrogen-bonding interactions. One of the two ...

A new class of tridentate pyridine-bis(oxazoline) ligand having gem-diphenyl groups at C5 of the oxazoline rings has been developed. Its metal complex exhibited high catalytic efficiency in asymmetric synthesis. We have shown that gem-diphenyl groups at C5 of the oxazoline rings are essential for getting high enantiomeric excess.