The title compound, C(26)H(24)FNO(3), is a critical inter-mediate of a selective and competitive inhibitor of the enzyme 3-hy-droxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. Inter-molecular N-H⋯O hydrogen bonding generates a chain along [give direction] that is the dominant inter-action in the crystal packing. Inter-molecular C-H⋯O inter-actions are also observed.

In this scheme, the racemase involves a rearrangement of the hydrogen about the asymmetrical carbon (6,7), while the mutase reaction involves an intramolecular migration (8, 9) of the thioester group (l&12). Two approaches are available to determine the source of the hydrogen that arises on carbon 3 of succinyl-CoA as a result of methylmalonyl-Coil mutase action. The first or indirect approach,...

The aim of this study was to investigate the possible existence and magnitude of stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). The catalytic portion of HMGR was expressed and purified. The reaction product mevalonate was lactonized and extracted from the reaction mixture by a solid-phase extraction protocol. Stable carbon isotope ratios of...

In this paper the need for employing a data reduction algorithm in using digital graphic systems to display biomedical signals is firstly addressed and then, some such algorithms are compared from different points of view (such as complexity, real time feasibility, etc.). Subsequently, it is concluded that Turning Point algorithm can be a suitable one for real time implementation on a microproc...