The primary focus in the network-centric analysis of cellular metabolism by systems biology approaches is to identify the active metabolic network for the condition of interest. Two major approaches are available for the discovery of the condition-specific metabolic networks. One approach starts from genome-scale metabolic networks, which cover all possible reactions known to occur in the relat...

The mammalian yolk sac is known to play a prominent role in emergence of the hematopoietic system. The extent of this contribution has been a subject of debate in recent years largely due to effects of the early circulation that obscures the site of origin of hematopoietic stem and progenitor cells. This review discusses the limitations of some of the standard assays currently employed to study...

This paper deals with wordnet development tools. It presents a designed and developed system for lexical database editing, which is currently employed in many national wordnet building projects. We discuss basic features of the tool as well as more elaborate functions that facilitate linguistic work in multilingual environment.

OBJECTIVE This investigation sought to examine whether methods proposed to control the healthy worker survivor effect would influence the shape or magnitude of the dose-response curve for respiratory cancer induced by arsenic. METHODS Results from an unadjusted analysis are compared with results obtained by applying four different methods for control of the healthy worker survivor effect to d...

Unemployment and job insecurity have been reported to be associated with a higher risk of depression. The purpose of this study was to evaluate the separate and combined effects of lifetime unemployment experience and job insecurity on the incidence of depression in an unselected working population in Germany. Data from the German Socio-Economic Panel (GSOEP) study were used, as was a final sam...

In the paper there is discussed a mathematical framework suitable for speciica-tional problems of modern theory of databases. The main thesis is that a proper framework for a majority of hot problems should be built on the ground of graph-based logic and algebra as opposed to string-based logics and algebras over sets currently employed in the DB theory. Such a graph-based machinery was develop...