The recent development of new gold(I) catalysis methodologies has opened the door to new disconnections for the total synthesis of bioactive complex molecules. Below is described the application of a gold(I)-catalyzed hydroarylation of an allene with indole toward the total synthesis of flinderoles B-C, members of a new class of antimalarial bisindole alkaloids isolated from plants of the Flind...

The total synthesis of apoptolidin (1) is reported together with the design, synthesis, and biological evaluation of a number of analogues. The assembly of key fragments 6 and 7 to vinyl iodide 3 via dithiane coupling technology was supplemented by a second generation route to this advanced intermediate involving a Horner-Wadsworth-Emmons coupling of fragments 22 and 25. The final stages of the...

Fully conjugated pyrene-anthracene-based molecular rods were synthesized by the Horner-Wadsworth– Emmons reaction utilizing potassium tert-butoxide in dry THF. The synthesized rods, which have butylene groups as solubility spacers in the main chain, exhibited good solubility in polar solvents. The solutions of the synthesized pyrenecontaining molecular rods exhibited a blue shift in the UV-vis ...

BACKGROUND Chiral base desymmetrisation of dimethyl sulfoximines could provide a general route to chiral, enantioenriched dialkyl sulfoximines with potential for use in asymmetric catalysis. RESULTS Asymmetric deprotonation of N-trialkylsilyl dimethyl sulfoximines with either enantiomer of lithium N,N-bis(1-phenylethyl)amide in the presence of lithium chloride affords enantioenriched sulfoxim...

* I am grateful to Jeffrey Bernstein for helpful discussions. This paper has also benefited from discussions with Irv Emmons, Neil Langland and staff members at numerous public service commissions. The usual caveat applies. Abstract A growing concern on the part of regulators is that price regulation may weaken incentives for investment in service quality. Participation by the firm in complemen...

Virgin females of the parasitoid wasp Trichogramma turkestanica produce minute amounts of a sex pheromone, the identity of which has not been fully established. The enantioselective synthesis of a putative component of this pheromone, (6S,8S,10S)-4,6,8,10-tetramethyltrideca-2E,4E-dien-1-ol (2), is reported as a contribution to this identification. Catalytic asymmetric conjugate addition of meth...

Chemical isolation in the Asian monsoon anticyclone observed in Atmospheric Chemistry Experiment (ACE-FTS) data M. Park, W. J. Randel, L. K. Emmons, P. F. Bernath, K. A. Walker, and C. D. Boone National Center for Atmospheric Research, Boulder, Colorado, USA Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada Department of Chemistry, University of York, Heslington, York, ...

S. Tilmes, L. K. Emmons, K. S. Law, G. Ancellet, H. Schlager, J.-D. Paris, H. E. Fuelberg, D. G. Streets, C. Wiedinmyer, G. S. Diskin, Y. Kondo, J. Holloway, J. P. Schwarz, J. R. Spackman, T. Campos, P. Nédélec, and M. V. Panchenko National Center for Atmospheric Research, Boulder, Colorado, USA LATMOS-IPSL; UPMC Univ. Paris 06; Univ. Versailles St-Quentin; CNRS/INSU, Paris, France Institute fo...

The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative activity against a variety of human cancer cell lines. Two highly active analogs of dictyostatin, 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, were prepared by a new streamlined total synthesis route. Three complete carbon fragments were prepared to achieve maximum convergency. The...