Graves's disease (diffuse toxic goitre) Toxic nodular goitre Multinodular (Plummer's disease) Uninodular (toxic adenoma) Nodular goitre with Graves's disease Excess thyroid stimulating hormone Pituitary tumour Choriocarcinoma and hydatidiform mole Embryonal testicular carcinoma Other malignancy (?) Extraneous thyroid hormone Exogenous: Intentional factitious Overenthusiastic therapy During T-3 ...

Hexamethylene bisacetamide (HMBA) induces in vitro the cytodifferentiation of PCC3/A/1 mouse embryonal carcinoma (EC) cells. In EC cells, actin is associated with surface structures but microfilament bundles are not seen. After 2 days of HMBA treatment, rounded EC cells are converted to flat adhesive ones with a developed cytoskeleton containing actin and tropomyosin. The ratio of actin to tota...

Cancers are thought to be rarer in younger population, but emerging data show an increasing incidence of these diseases. The aim of this study was to evaluate the clinicopathological characteristics of cancer among young patients (≥30 years) in Uyo, Nigeria. All specimens were collected and reviewed during the period January 2007-December 2012; complete clinicopathological data were also consid...

The histogenetic and neoplastic potentials of defined regions of the 8th day mouse embryonic egg cylinder were examined following ectopic transfer to beneath the testis capsule. No differences in histogenetic potential were detected between anterior and posterior slices of the embryo, either when composed of all three germ layers or of embryonic ectoderm alone. Small anterior and distal fragmen...

Fetal rhabdomyoma is not generally considered part of nevoid basal cell carcinoma syndrome. However, a review of the literature revealed five patients with this syndrome who also had fetal rhabdomyomas in various locations. We report the first patient with nevoid basal cell carcinoma syndrome and a fetal rhabdomyoma of the tongue. We recommend that embryonal rhabdomyosarcoma be ruled out to avo...

An immunohistologic study of 21 patients with germ cell tumors of the testis with m easured serum levels o f hum an chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) was undertaken to correlate the various types of neoplasms with the presence of these tum or markers in the tissue and serum. The same immunoperoxidase technique was applied to 48 patients with m alignant germ cell tumors of...

Murine embryonal carcinoma tumors were induced to differentiate in vivo by administration of retinoic acid. Six long-term surviving animals had seven slowly growing tumors which were transplanted s.c. into strain 129 mice. Untreated embryonal carcinomas were transplanted as controls. All of the 16 control transplants grew rapidly and killed their hosts within 25 days. All of the 24 transplants ...

BACKGROUND There is only limited knowledge about gene expression in human testicular germ cell tumors of adolescents and adults (TGCTs), and, in particular in its preinvasive stage intratubular germ cell neoplasia unclassified (IGCNU). MATERIALS AND METHODS Global gene expression was studied in 10 invasive human testicular germ cell tumors (TGCTs), 7 intratubular germ cell neoplasia unclassif...