In 2007, the Human Fertilisation and Embryology Authority in London, UK, published "Hybrids and Chimeras: A Report on the Findings of the Consultation", which summarized a public debate about research on, and suggested policy for, human animal chimeras [4]. The HFEA formulated the report after conducting a series of surveys and debates from earlier in 2007. The HFEA issued a statement in Septem...

OBJECTIVE To evaluate the usefulness of preimplantation genetic screening (PGS) using array comparative genomic hybridization (aCGH) in the Indian population. MATERIALS AND METHODS This is a retrospective, multicenter study including 235 PGS cycles following intracytoplasmic sperm injection performed at six different infertility centers from September 2013 to June 2015. Patients were divided ...

In 2007, the Human Fertilisation and Embryology Authority in London, UK, published "Hybrids and Chimeras: A Report on the Findings of the Consultation", which summarized a public debate about research on, and suggested policy for, human animal chimeras [4]. The HFEA formulated the report after conducting a series of surveys and debates from earlier in 2007. The HFEA issued a statement in Septem...

In 2007, the Human Fertilisation and Embryology Authority in London, UK, published "Hybrids and Chimeras: A Report on the Findings of the Consultation", which summarized a public debate about research on, and suggested policy for, human animal chimeras [4]. The HFEA formulated the report after conducting a series of surveys and debates from earlier in 2007. The HFEA issued a statement in Septem...

The need to identify the most viable embryo following in vitro fertilization (IVF) was established early in the history of human IVF. The stalwart of identifying the best embryos has been morphology. Other techniques have however seen wide acceptance, including the use of preimplantation genetic screening, even though concerns exist over the invasive nature of the technique. Alternatively, noni...

Many published papers suggest a favourable impact of preimplantation genetic screening (PGS) on implantation and pregnancy rates, but more recent randomized studies have not confirmed, or could not conclude, that PGS actually improved implantation rates. Team inexperience in embryo screening has been mentioned as the origin of the discrepancies; thus some clinicians allege a need for more power...

Preimplantational Genetics Diagnosis (PGD) is requested by geneticists and reproductive specialists. Usually geneticists ask for PGD because one or both members of the couple have an increased genetic risk for having an affected offspring. On the other hand, reproductive specialists ask for embryo aneuploidy screening (PGS) to assures an euploid embryo transfer, with the purpose to achieve an o...

Largely because of efforts required to complete the Human Genome Project, DNA sequencing has undergone a steady transformation with still-ongoing developments of high-throughput sequencing machines for which the cost per reaction is falling drastically. Similarly, the fast-changing landscape of reproductive technologies has been improved by genetic approaches. Preimplantation genetic diagnosis ...

The use of rodent models to evaluate efficacy during testing is accompanied by significant economic and regulatory hurdles which compound the costs of screening for promising drug candidates. Vasopermeation Enhancement Agents (VEAs) are a new class of biologics that are designed to increase the uptake of cancer therapeutics at the tumor site by modifying vascular permeability in the tumor to in...

BACKGROUND Although preimplantation genetic screening (PGS) is widely offered, there are contradictory reports on the clinical merit of this procedure. Any gain from embryo selection following aneuploidy screening must significantly outweigh the impact of the procedure. Variability of technical expertise in embryo biopsy, blastomere fixation, fluorescence in situ hybridization analysis, along w...