Although the epileptogenic properties of estrogens have been widely demonstrated in several models and species, the mechanism(s) by which estrogens can acutely change seizure parameters including after discharge and seizure duration remain remains to be determined. In the present study, we examined the role of NMDA (N-methyl-D-aspartate), non-NMDA and estrogenic receptors in estradiol benzoate ...

Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged intervals. Polymeric films were designed with various compositions of hydroxypropyl ...

In this study, the effect of ethylene on rheological and mechanical properties rubbers was investigated. For purpose, were produced by mixing EPDM containing in different ratios curing with sulfur. The formulations modified so that all samples had same hardness. Rheometer analysis results revealed flow consistency Suprene 512 F sample higher than other two samples. time 90% later As a result te...

hdpe monofilaments were obtained using different extruders and drawn by post-extruder equipments. after solidification, drawn and undrawn monofilaments (draw ratio 7:1) were irradiated with 10 mev electron beams in air at room temperature at 25, 50, 75, 100 and 125 kgy dose ranges to induce a network structure. hdpe crosslinking was studied on the basis of gel content measurements. the fibers w...

introduction: memory and cognitive impairments are some of devastating outcomes of multiple sclerosis (ms) plaques in hippocampus, the gray matter part of the brain. the present study aimed to evaluate the intrahippocampal injection of ethidium bromide (eb) as a simple and focal model to assess cognition and gray matter demyelination. methods: thirty wistar rats were divided into three groups: ...

This study aimed to investigate the impact of heat treatment on properties soy protein isolate film-forming solutions. The solutions, consisting isolate, glycerol, and phosphate buffer solution (pH 7.4), were subjected at 65, 75, 85°C for 2, 4, or 6 h. resulting films then analyzed tensile strength, elongation break, film solubility, color parameters, transparency. results indicated that increa...