The EEG bipolar power spectra provide more localization than spectral measures obtained from monopolar referencing strategies, and have been shown to be useful endophenotypes of psychiatric disorders such as alcoholism. We estimated the additive genetic heritability of resting bipolar EEG power spectra in a large sample of non-twin sibling pairs. The corresponding heritabilities ranged between ...

glioblastoma is the most common and the most lethal primary brain cancer. this malignancy is highly locally invasive, rarely metastatic and resistant to current therapies. little is known about the distinct molecular biology of glioblastoma multiforme (gbm) in terms of initiation and progression. so far, several molecular mechanisms have been suggested to implicate in gbm development. homeodoma...

1. Balkany TJ, Connell SS, Hodges AVet al. Conservation of residual acoustic hearing after cochlear implantation. Otol Neurotol 2006;27:1083-8. 2. von Ilberg C, Kiefer J, Tillein Jet al. Electric-acoustic stimulation of the auditory system. New technology for severe hearing loss. ORL; journal for oto-rhino-laryngology and its related specialties 1999;61:334-40. 3. Gantz BJ, Turner CW. Combining...

We have studied conduction anaesthesia of the median and ulnar nerves at the axilla using mixed nerve action potentials (MNAP) as a guide to needle position in three volunteers. The median and ulnar nerves were stimulated distally at the wrist using surface electrodes and MNAP were detected proximally in the axilla using an insulated needle electrode. The increase in amplitude of MNAP to maximu...

This study describes novel methods for supporting navigation and placement of electrodes during surgeries for deep brain stimulation (DBS). Critical to these procedures in neurosurgery is the localization and identification of different target structures along the electrode's trajectory in the brain such as the subthalamic nucleus (STN), and finding the best position for the stimulating electro...

BACKGROUND Recommendations regarding the technical aspects of nerve stimulator-assisted nerve localization are conflicting. The objectives of this study were to determine whether the placement of the cutaneous electrode affects nerve stimulation and to determine the duration and intensity of an electrical stimulus that allows nerve stimulation with minimal discomfort. METHODS Ten healthy volu...

Latex micrometric beads are manipulated by optical tweezers in the vicinity of an ultramicroelectrode (UME). They are optically trapped in solution and approached the electrode surface. After the electrochemical measurement, they are optically removed from the surface. The residence time of the particle on the electrode is thus controlled by the optical tweezers. The detection is based on diffu...

Electrophysiological recordings from subdural electrocorticography (ECoG) electrodes implanted temporarily during deep brain stimulation (DBS) surgeries offer a unique opportunity to record cortical activity for research purposes. The optimal utilization of this important research method relies on accurate and robust localization of ECoG electrodes, and intraoperative fluoroscopy is often the o...

OBJECT There is a growing interest in the use of recording from the surface of the brain, known as electrocorticography (ECoG), as a practical signal platform for brain-computer interface application. The signal has a combination of high signal quality and long-term stability that may be the ideal intermediate modality for future application. The research paradigm for studying ECoG signals uses...