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objective(s) this study was carried out in order to evaluate the effects of electrochemotherapy, electrical pulses and chemotherapeutic drugs on the killing of cancerous cells and their probable synergistic effects. materials and methods electrochemotherapy treatments conducted on mcf-7 cell line derived from human breast adenocarcinoma tumor using four chemotherapeutic drugs including bleomyci...

BACKGROUND Electrochemotherapy and gene electrotransfer are novel promising treatments employing locally applied high electric pulses to introduce chemotherapeutic drugs into tumor cells or genes into target cells based on the cell membrane electroporation. The main focus of this paper was to calculate analytically and numerically local electric field distribution inside the treated tissue in t...

INTRODUCTION: The skeleton is a common site of metastases for a number of different cancers. They include lung, breast, prostate, kidney, thyroid cancers and multiple myeloma. It has been reported that in 70% of patients with metastatic breast cancer, bone metastases will develop [1]. Cancer cells in bone disrupt normal bone remodelling, resulting in the case of breast tumour cells in osteolyti...