نتایج جستجو برای: ee ratio
تعداد نتایج: 511788 فیلتر نتایج به سال:
The key step in the chemoenzymatic synthesis of apremilast was to produce chiral alcohol (R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanol, (R)-3. Two enzymatic approaches were evaluated obtain (R)-3, one using ketoreductases and other lipases. Bioreduction 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone (2), ketoreductase KRED‑P2-D12, led (R)-3 with 48% conversion 93% enantiom...
An enriched environment has been shown to influence brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF). BDNF, which is synthesized as a precursor molecule (proBDNF) that undergoes proteolytic cleavage, plays an important role in synaptic plasticity and contributes to several brain functions such as memory, learning, and behavior. The neurotrophins ...
سابقه و هدف: دیسمنوره اولیه یکی از شکایات شایع زنان است. هدف از این مطالعه مقایسه اثر ویتامین e و عصاره رازیانه روی دیسمنوره اولیه است. مواد و روش ها: یک کارآزمایی بالینی تصادفی یک سوکور و کنترل شده با دارونما در میان 75 دانشجوی دختر انجام گرفت. شرکت کنندگان در مطالعه به سه گروه عصاره رازیانه، ویتامین e و دارونما تقسیم شدند. گروه ها برای 2 ماه متوالی درمان را از روز اول درد به مدت 3 روز برای 4 ...
The efficient asymmetric hydrosilylation of imines in the presence of polymethylhydrosiloxane has been investigated by screening chiral diamine-zinc complexes. A series of chiral diamine ligands were prepared from optically pure 1,2-diphenyl-1,2-ethanediamine and screened for effectiveness. N-Benzylic substituents were required for high enantioselectivity; ligands with bulky groups or extra coo...
17 alpha-Ethynylestradiol (EE), a major constituent of many oral contraceptives, inactivated the testosterone 6 beta-hydroxylation activity of purified P450 3A4 reconstituted with phospholipid and NADPH-cytochrome P450 reductase in a mechanism-based manner. The inactivation of P450 3A4 followed pseudo first order kinetics and was dependent on NADPH. The values for the K(I) and k(inact) were 18 ...
A measurement of the vector to pseudoscalar conversion decay φ → πee with the KLOE experiment is presented. A sample of ∼ 9500 signal events was selected from a data set of 1.7 fb of ee collisions at √ s ∼ mφ collected at the DAΦNE ee collider. These events were used to obtain the first measurement of the transition form factor |Fφπ0(q)| and a new measurement of the branching ratio of the decay...
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