Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found that PTBP1 binding in the flanking introns allowed normal U2AF and U1 snRNP binding to the target exon splice sites but blocked U2 snRNP assembly in H...

Enteric duplication cysts (EDCs) can occur in any portion of the alimentary tract, but are most commonly associated with the small bowel and esophagus. Retroperitoneal location is really unusual. This 19-year-old female was in excellent health, but a week's abdominal pain made her search for a doctor's help. After the detailed examination, surgical intervention was performed under the impressio...

Data handling of pivotal clinical trials and their open label extensions is always a challenging task. Using the latest methods of Electronic Data Capture (EDC) correctly combined with the powers of SAS we can meet this challenge successfully. An open-label extension can accept patients from more than one trial of the same study drug. All the trials leading to the same open-label extension are ...

Project Description: Background & Purpose In the fall of 2001 CCNMTL, in partnership with the School of General Studies, opened the Experimental Digital Classroom (EDC) for working with faculty to explore using new technologies in their courses. In line with the Center’s philosophy of the role of new media in teaching and learning, the EDC was designed to maximize the pedagogical usefulness of ...

Liver concentrations of selected pollutant classes were determined in groups of sheep fetuses and their dams, at 55 (Experiment 1) and 110 (Experiment 2) days of gestation (term = 145 d) following exposure, throughout their breeding lives and after mating, to pasture treated with either inorganic fertiliser (control, CC) or with sewage sludge (treated, TT). In a unique study designed to separat...

Many ailments can be linked to exposure to indoor airborne fungus. However, obtaining a precise measurement of airborne fungal levels is complicated partly due to indoor air fluctuations and non-standardized techniques. Electrostatic dust collector (EDC) sampling devices have been used to measure a wide range of airborne analytes, including endotoxins, allergens, β-glucans, and microbial DNA in...

BACKGROUND Glutaraldehyde (GA) is a widely used cross-linking agent for improving mechanical properties and resistance to enzymatic degradation of collagenous tissue, but it has several drawbacks such as calcification and cytotoxicity. The aim of this study was to find the alternative effective cross-linking methods to GA. MATERIALS AND METHODS Bovine pericardium was processed with GA with et...

Psoriasis vulgaris is a complex, inflammatory skin disease of the skin affecting 2% of Western populations. Genetic linkage analysis with extended U.S. and Italian families and gene expression studies implicate genetic variation at 1q21 (PSORS4) in conferring psoriasis susceptibility. A 2.5 Mb region on 1q21 harbors the gene rich Epidermal Differentiation Complex (EDC), whose genes have importa...

OBJECTIVE Initial treatment with antidepressant medication is insufficiently effective in some patients with type 2 diabetes, and factors predicting treatment outcome are poorly understood. RESEARCH DESIGN AND METHODS Aggregate data from two published trials were analyzed to determine the rates and predictors of response to antidepressant pharmacotherapy in adults with type 2 diabetes using con...

Frequency of firing and regularity of discharge of human motor units, and short term synchrony between pairs of motor units, have been assessed in extensor digitorum communis (EDC) and tibialis anterior (TA) muscles in control subjects and in clinically complete paraplegic subjects. The discharge pattern of TA motor units in paraplegia ranged from extremely regular to very irregular for differe...