Atopic dermatitis is a common condition in children that is characterized by atopic eczematous skin rash that is highly pruritic. Children with atopic dermatitis might have other immunologic disorders, such as asthma and food allergies. The diagnosis of atopic eczema due to atopic dermatitis in children is a clinical-based one with little value of laboratory investigations. Once the diagnosis i...

Objective. To describe the clinical characteristics of IPEX syndrome in a child with FOXP3 mutation. Clinical Case. A boy aged 2.3 years was born from first normal pregnancy with a weight of 3420 gr. Family History. Two brothers of the mother died before the age of 3 years with severe infections, diarrhea, erythroderma, and elevated immunoglobulins class E (IgEs). Since first month of life, our...

Increased dermal mucin is a feature of lupus erythematosus (LE); however, its amount and distribution have not been well characterized. The differentiation of LE from other forms of dermatitis can be challenging when other features of LE are subtle or equivocal. One hundred and thirty-five skin specimens showing LE, graft vs. host disease, erythema multiforme/fixed drug eruption, lichen planus,...

Leishmaniasis is a infectious disease with broad spectrum of clinical features from typical noduloulcerative lesion to atypical lesions. In this article, we presented 4 cases with atypical presentation of cutaneous leishmaniasis lesions (including eczematous, sporotrichoid and lichenoid) in an endemic area in Iran, Kerman. The first case was a 28- year- old man presented with a pruritic purplis...

Job’s syndrome is characterized by the clinical features of fair skin, red hair, recurrent cold, staphylococcal skin abscesses with concurrent other bacterial infections and skin lesions. Hyperimmunoglobulin E syndrome (HIES) is a rare immune deficiency presenting with a trial of recurrent skin and pulmonary infections elevated IgE and eczematous reactions. The aim of this article is to review ...

Atopic eczema (also known as atopic dermatitis) is a very common inflammatory skin condition.(Guidelines 2006) It is characterised by an itchy red rash that typically tends to involve the skin creases (e.g. behind the knees, folds of elbows, around the neck), and is usually relatively mild.(Emerson 1998) In the acute stage, eczematous lesions are poorly defined and red with oedema, vesicles, an...

Background Wiskott–Aldrich syndrome (WAS) is a rare X-linked recessive disorder characterized by early microthrombocytopenia, eczematous skin disease and recurrent infections. The syndrome is caused by mutations in gene WAS which codes WASP protein, that is expressed selectively in hematopoietic cells and it is involved in cell signaling and cytoskeleton reorganization. Microthrombocytopenia is...

Sir, Contact of the skin with metals can induce several types of cutaneous reactions, mainly eczematous skin lesions. However, the increasing tendency to use metallic implants in the skin, mainly by the young populations, is leading to the appearance of other types of cutaneous reactions that can be difficult to differentiate from other infectious and noninfectious cutaneous disorders. We repor...

Background Skin diseases produce a negative impact on the psychoemotional state, social relationships and daily activities. This effect should be particularly important during childhood, a critical period for physical and psychosocial development. However, there is a scarcity of publications on the impact of dermatological diseases in the pediatric population. Atopic eczema (AE) is a chronic ec...

Pegylated or non-pegylated α-interferon are frequently used medications for the treatment of both chronic hepatitis B and chronic hepatitis C. Skin disorders, which are mainly comprised of eczematous dermatitis, are frequently seen during treatment with this drug. However, drug eruption or morbilliform eruptions due to interferons have been rarely reported so far. We herein describe a patient w...