BACKGROUND The use of antracycline (ANT) in breast cancer has been associated with adverse cardiac events. Two-dimensional (2D) strain imaging (SI) can provide a more sensitive measure of altered left ventricular (LV) systolic function. We aimed to evaluate the preventive effect of carvedilol administration assessed by SI in a patient with breast cancer treated with ANT. METHODS Patients rece...

OBJECTIVES Pericardial effusion (PE) is correlated with outcomes in patients with pulmonary arterial hypertension (PAH). Pulmonary artery denervation (PADN) was used for treatment of PAH. The present study aimed to analyze the prognostic value of PE for outcomes after PADN in patients with WHO Group I, Group II and Group IV PAH. RESULTS PE, frequently seen in patients with connective tissue d...

A case is presented of a 60-year-old man who sustained spinal and chest wall injuries following a collision between his glider and an aeroplane. The severity of his injuries required him to be managed with bilateral underwater seal drains, cervical spine stabilisation and sedation with mechanical ventilation. Due to the severity of his chest trauma, a transoesophageal echocardiograph was perfor...

Background: How can mathematics help us to understand the mechanism of the cardiac motion? The best known approach is to take a mathematical model of the fibered structure, insert it into a more-or-less complex model of cardiac architecture, and then study the resulting fibers of activation that propagate through the myocardium. In our paper, we have attempted to create a novel software capable...

BACKGROUND Despite correction of left-sided cardiac lesions, associated functional tricuspid regurgitation (TR) that was surgically ignored can persist. It can also appear de novo. The aim of this study was to analyze TR in a group of patients who underwent successful revascularization and mitral valve repair (MVRep) for functional ischemic mitral regurgitation (MR). METHODS AND RESULTS Among...

AIMS The coronary artery ligation model in rodents mimics human myocardial infarction (MI). Normally mechanical ventilation and prolonged anesthesia period are needed. Recently, a method has been developed to create MI by popping-out the heart (without ventilation) followed by immediate suture ligation. Mortality is high due to the time-consuming suture ligation process while the heart is expos...

A 70 year old female was admitted to the Emergency Department of our Hospital after an episode of syncope, at home. The patient was resuscitated with chest compressions. The patient’s family history was clear. Her own medical history revealed a transient cerebral ischemic attack. No other significant disease was reported. Despite the detailed history taken, no history of thoracic pain, dyspnea ...

A case-control study on the morbidity of Chagas heart disease was carried out in the municipality of Barcelos in the microregion of the Rio Negro, state of Amazonas. One hundred and six individuals, who were serologically positive for Trypanosoma cruzi infection, as confirmed by at least two techniques with different principles, were matched according to age and sex with an equal number of sero...

Objective: To evaluate left ventricular mass (LVM) and diastolic function in hypertension patients by RealTime Three-Dimensional Echocardiograph (RT-3DE). Methods: A total of 50 healthy subjects (as control group) and 50 subjects with essential hypertension and left ventricular filling disorders (as hypertension group) were enrolled in the study, and partial general echocardiographic parameters...

In contrast to skeletal muscles that simultaneously express multiple troponin T (TnT) isoforms, normal adult human cardiac muscle contains a single isoform of cardiac TnT. To understand the significance of myocardial TnT homogeneity, we examined the effect of TnT heterogeneity on heart function. Transgenic mouse hearts overexpressing a fast skeletal muscle TnT together with the endogenous cardi...