Background Dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides are the main alkamides in Echinacea preparations, which have been demonstrated to possess biological activities in various bio-assays, such as immune-modulating activities and effects on cannabinoid receptors [1]. Therefore, the evaluation of systemic availability of these active plant constituents is a major prerequisite for the i...

In the present paper are discussed the results of the investigations of the phenylpropanoids of the medicinal plants which are of the great interest as the sources of the neurotropic, adaptogenic, immunostimulating, antioxidative, and hepatoprotective preparations. There were shown the necessity of using of the standard samples of triandrin (Rhodiola rosea L. tissue cultures, Salix viminalis L....

objective(s) there are some reports that the teratogenic effects of cyclophosphamide (cpa) can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. echinacea purpurea extract is antioxidative and immunomodulator drug. mesna (sodium 2-mercaptoethane sulfonate) is used for decreasing side effects of cpa, especially hemorrhagic cystitis. in this study, we...

Echinacea species are used for beneficial effects on immune function, and various prevalent phytochemicals have immunomodulatory effects. Using a commercial E. purpurea (L.) Moench product, we have evaluated the myelopoietic effect on bone marrow of rats treated with various extracts and correlated this with their chemical class composition. Granulocyte/macrophage-colony forming cells (GM-CFCs)...

Commercial Oregano oils with high concentrations of carvacrol have been vigorously promoted as antiviral agents effective against colds and ‘flu, including the pandemic H1N1 virus. However there seems to be no evidence to support these claims. Furthermore, since carvacrol itself is known to be toxic, so-called “carrier oils”, such as olive oil, have been included in formulations to ameliorate t...

While radiation hazards, due to free radical generation, present an enormous challenge for biological and medical safety, Echinacea purpurea is a potent scavenger of a variety of free radicals. The aim of this study was to investigate the radioprotective effect of Echinacea purpurea against oxidative stress in spleen tissues and alterations in some immune responses. Rats were whole body irradia...

The aim of this open-label, fixed-sequence study was to investigate the potential of the botanical supplement Echinacea purpurea to interact with etravirine, a nonnucleoside reverse transcriptase inhibitor of HIV. Fifteen HIV-infected patients receiving antiretroviral therapy with etravirine (400 mg once daily) for at least 4 weeks were included. E. purpurea root/extract-containing capsules wer...

We announce here the draft genome sequence of Pseudomonas sp. strain EpS/L25, isolated from the stem/leaves of the medicinal plant Echinacea purpurea This genome will allow for comparative genomics in order to identify genes associated with the production of bioactive compounds and antibiotic resistance.

Echinacea (E.) purpurea herb is commonly known as the purple coneflower, red sunflower and rudbeckia. In this paper, we report the curative efficacy of an Echinacea extract in gamma-irradiated mice. E. purpurea was given to male mice that were divided into five groups (control, treated, irradiated, treated before irradiation & treated after irradiation) at a dose of 30 mg/kg body weight for 2 w...

Since years ago, phytopharmaceutical drugs have been used by various societies, as a traditional treatment. Echinacea purpurea (Asteraceae) is the best known of the dozen or so species of the genus Echinacea, a group of perennial prairie wildflowers native to the central grasslands of North American. E. purpurea is cultivated widely throughout the United states, Canada and Europe, although it h...