Gentamicin Clb is 6'-N-methylgentamicin Cia. This antibiotic is coproduced, as one of minor components, in the standard gentamicin fermentation. Kershner (Ph.D. thesis, Rutgers University, New Brunswick, N.J., 1971) first described its presence in trace amounts in gentamicin preparations. Daniels and co-workers (2) reported its isolation, purification, and characterization from fermentation bot...

Barbacenia purpurea is a resurrection species endemic to rock outcrops, in Rio de Janeiro, Brazil. It tolerates great temperature variations, which are associated to periods of up to 30 days without precipitation. Using a metabolomic approach, we analyzed, under winter and summer conditions, changes in the leaf metabolite profile (MP) of potted plants of B. purpurea submitted to daily watered a...

OBJECTIVE To investigate the safety and efficacy of 2 extracts of echinacea for preventing upper respiratory tract infections. DESIGN Three-armed, randomized, double-blind, placebo-controlled trial. SETTING Four military institutions and 1 industrial plant. PARTICIPANTS Three hundred two volunteers without acute illness at time of enrollment. INTERVENTIONS Ethanolic extract from Echinac...

Claviceps purpurea, the fungal pathogen that causes the cereal disease ergot, produces glycerides that contain high levels of ricinoleic acid [(R)-12-hydroxyoctadec-cis-9-enoic acid] in its sclerotia. Recently, a fatty acid hydroxylase (C. purpurea FAH [CpFAH]) involved in the biosynthesis of ricinoleic acid was identified from this fungus (D. Meesapyodsuk and X. Qiu, Plant Physiol. 147:1325-13...

background: nowadays, there's a growing demand for the natural antioxidants due to the harmful effects of synthetic antioxidants. therefore, introduction of new natural antioxidants (especially those with plant origin) is very important. objective: the present study explores the chemical constitution and antioxidant activity of leaf extract of hyssopus officinalis l. and extract of aerial ...

Mobile element dynamics in seven alleles of the chalcone synthase D locus (CHS-D) of the common morning glory (Ipomoea purpurea) are analyzed in the context of synonymous nucleotide sequence distances for CHS-D exons. By using a nucleotide sequence of CHS-D from the sister species Ipomoea nil (Japanese morning glory [Johzuka-Hisatomi, Y., Hoshino, A., Mori, T., Habu, Y. & Iida, S. (1999) Genes ...

Stipa purpurea (S. purpurea) is the dominant plant species in the alpine steppe of the Qinghai-Tibet Plateau, China. It is highly resistant to cold and drought conditions. However, the underlying mechanisms regulating the stress tolerance are unknown. In this study, a CIPK gene from S. purpurea (SpCIPK26) was isolated. The SpCIPK26 coding region consisted of 1392 bp that encoded 464 amino acids...

Alkylamides present in Echinacea species have reported immunomodulatory actions, yet their direct effects on T lymphocytes, key mediators of antiviral immunity, are poorly understood. We hypothesized that constituents present in ethanolic extracts of Echinacea species exert direct immunomodulatory effects on human Jurkat T cells. Modulation of IL-2 production by submaximally stimulated Jurkat c...

BACKGROUND Echinacea purpurea stimulates the immune response and is promoted to reduce symptom severity and the duration of upper respiratory tract infections. We sought to determine the efficacy of a standardized preparation of E purpurea in reducing symptom severity and duration of the common cold. METHODS A randomized, double-blind, placebo-controlled design was used. Patients received eit...

The process of angiogenesis and control of blood vessels sprouting are fundamental to human health, as they play key roles in many physiological and pathological conditions. Intake of different pharmaceuticals with antiangiogenic activity by pregnant women may lead to severe developmental disturbances as it was described in case of thalidomide. It may also cause immunomodulatory effects as it w...