OBJECTIVE The biosynthesis of endothelin-1 (ET-1), the most potent vasoconstrictor with mitogenic properties, involves the processing of intermediate protein big ET-1 by a unique metalloprotease, endothelin-converting enzyme-1 (ECE-1). ECE-1 has 4 subisoforms that possess the same catalytic properties but different localization patterns on the plasma membrane and cytosol. We investigated the tr...

An imbalance of nitric oxide and endothelin plays an important role in cardiovascular disease. Thrombin exerts profound effects on endothelial function. The present study investigated the molecular mechanisms by which thrombin regulates endothelial nitric oxide synthase (eNOS) and endothelin-converting enzyme (ECE)-1 expression in human endothelial cells. Incubation of human umbilical vein endo...

Copyright to IJAREEIE www.ijareeie.com 142 Immobilizer Implementation using Mutual Authentication with enhanced security using 802.15.4 protocol Mr.B.Karthik , Dr.T.V.U. Kiran Kumar , N. Gomathi Assistant Professor, ECE Department, Bharath University, Chennai – 600073, India #2 Professor, ECE Department, Bharath University, Chennai – 600073, India #3 PG Student, ECE Department, Bharath Universi...

Mobile no:9573548993, Fax:08645 247249, 3. Professor, Department of ECE, K L University K L University, Vaddeswaram, Guntur, A.P, India 1. [email protected] [email protected] 2. Professor, Department of ECE, K L University 4. Associate Professor, Department of ECE, K L University K L University, Vaddeswaram, Guntur, A.P, India 2. [email protected] [email protected]

Gary Spivey* ECE Department University of Maryland, USA and Rincon Research Corp. Tucson, AZ, USA [email protected] Shuvra S. Bhattacharyya* ECE Department and UMIACS University of Maryland, USA [email protected] Kazuo Nakajima† ECE Department University of Maryland, USA, and Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan [email protected]

The potent smooth muscle agonist endothelin-1 (ET-1) is involved in the local control of seminiferous tubule contractility, which results in the forward propulsion of tubular fluid and spermatozoa, through its action on peritubular myoid cells. ET-1, known to be produced in the seminiferous epithelium by Sertoli cells, is derived from the inactive intermediate big endothelin-1 (big ET-1) throug...

Endothelin-1 (ET-1) has been implicated in the progression of various cancers, including ovarian carcinoma. We found that the ovarian carcinoma cell lines ES2 and OVCAR3 and tumors from different anatomic sites expressed ET-1 system members [ET receptor A and ET-converting enzyme-1 (ECE-1)]. However, only ECE-1 was significantly higher in the solid tumors compared with effusions. We therefore i...

PURPOSE To assess the ability of preoperative variables to predict extracapsular extension (ECE) and positive surgical margin (PSM) in radical prostatectomy patients with prostate-specific antigen (PSA) levels of less than 10 ng/ml. MATERIALS AND METHODS From January 2008 to December 2009, 121 patients with prostate cancer with PSA levels lower than 10 ng/ml who underwent radical prostatectom...

Increase in arterial stiffness is associated with aging, which is improved by regular exercise. Endothelin (ET) system has crucial roles in regulating vascular tone and in the progression of atherosclerosis. We hypothesized that molecular variations (ie, gene polymorphisms) in ET-related gene might affect exercise-induced improvement in arterial stiffness with age in human subjects. The present...

The potent vasoconstrictor endothelin-1 (ET-1) is secreted constitutively by endothelial cells and has been implicated in the pathophysiology of several cardiovascular diseases. It is generated from its inactive intermediate, big ET-1, through the action of endothelin-converting enzyme (ECE). Using several complementary techniques, we have demonstrated that ECE is present at the cell surface an...