Using an anti-NHE1 antibody, we demonstrate the presence of a Na+/H+ exchanger of isoform 1 (NHE1) in the human eccrine sweat duct. A strong staining was observed at the basolateral membrane of the outer cell layer (NHE1basal), at the junction between inner and outer cells layers (NHE1inter), and along the lateral membranes (NHE1later) of all cells of the duct. At the luminal membrane, no stain...

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is an uncommon, benign dermatosis and is characterized by asymptomatic grouped keratotic papules and plaques with a linear pattern on the extremities. Various treatments, including topical steroids, topical calcipotriol, topical 5-fluorouracil, retinoid, cryotherapy, and carbon dioxide laser ablation have been tried for PEODDN, but the...

We present a case of sclerosing syringoid carcinoma of the finger, a type of eccrine sweat duct malignancy that is rare and mimics the appearance of a benign lesion, but is locally aggressive and has a tendency to recur. It has seldom been reported in the literature. It has a predilection for the head and neck region but is rare in the extremities. We believe this is the second reported case of...

Nodular hidradenoma (HA) otherwise called as solid cystic HA/ Eccrine acrospiroma originate from distal excretory duct of sweat gland [1]. Origin from apocrine gland of breast has been seldom noted. It’s slow growing benign freely mobile solitary tumor with solid cystic consistency. Scalp, face and extremities are common locations. The usual age of presentation is 20-50 years showing female pre...

Pilar cysts are common squamous-lined cysts that typically occur on the scalp. They are believed to arise from the isthmus of anagen hairs or from the sac surrounding catagen and telogen hairs. The authors describe a rare case of a pilar cyst with prominent ductal differentiation, presumably of eccrine derivation. Sweat duct differentiation has been described in a myriad of cutaneous neoplasms ...

Eccrine poroma is a benign neoplasm thought to originate from the eccrine sweat glands. The majority of eccrine poroma occur on the hairless acral surface, and cases of eccrine poroma on the scalp are rare. Moreover, all these case reports describe only the histopathological, not radiological, features of eccrine poroma. Here, we first report the magnetic resonance (MR) findings in a rare case ...

A new method of isolating human eccrine sweat glands by the repeated dissection of skin biopsies with scissors is described. The success of the technique is attributed to a potential line of weakness between the investing capsule and the surrounding connective tissue, which parts under shear forces. The yield is 20-50 glands per biopsy (5 cm X 0.5 cm). The glands are judged to be viable by: (i)...

Introduction: Poroid hidradenomas (PH) are rare benign skin adnexal tumours with eccrine differentiation. PH have features of both poroma and hidradenoma, wholly intradermal. Few been reported in the literature, here we present two cases localised to left knee. The common histological examination finding was a circumscribed cyst lined by basaloid cells resembling poroma, occasional ductal struc...