Generic clinical study data management systems can record data on an arbitrary number of parameters in an arbitrary number of clinical studies without requiring modification of the database schema. They achieve this by using an Entity-Attribute-Value (EAV) model for clinical data. While very flexible for creating transaction-oriented systems for data entry and browsing of individual forms, EAV-...

Both glycogen and amylopectin are branched chain polyglucosides. A differentiation has most often been made on the basis of differences in the degree of branching of the two polysaccharides. For large molecular weight, highly ramified structures like glycogen and amylopectin, the number of branch points may be considered to be equal to the number of terminal, non-reducing glucose residues (end-...

We have analyzed the genome of the domestic chicken for the presence of genetic sequences related to the envelope protein-encoding genes of avian sarcoma/leukosis retroviruses to determine the organization, structure, potential functionality, and distribution of such sequences. We have previously identified in the genus Gallus an extensive group of endogenous avian retroviruses termed EAV-0. So...

Many groups of plus-stranded RNA viruses produce additional, subgenomic mRNAs to regulate the expression of part of their genome. Arteriviruses and coronaviruses (order Nidovirales) are unique among plus-stranded RNA viruses for using a mechanism of discontinuous RNA synthesis to produce a nested set of 5'- and 3'-coterminal subgenomic mRNAs, which serve to express the viral structural protein ...

Abbreviations: ABB: Aggregated Biomedical-information Browser; OLAP: On-Line Analytical Processing; DW4TRL: Data Warehouse for Translational Research; MOLAP: Multidimensional On-Line Analytical Processing; CBCP: Clinical Breast Care Project; IRB: Institutional Review Board; EAV: Entity Attribute Value; ISIV: Individual Subject Information Viewer; BMI: Body Mass Index; ER: Estrogen Receptor; PR:...

Three murine monoclonal antibodies (MAbs) that neutralize equine arteritis virus (EAV) infectivity were identified and characterized. The antibodies, 93B, 74D(B) and 38F, recognized the major envelope glycoprotein (GL) encoded by open reading frame (ORF) 5 in immunoblots and by immunoprecipitation. All three MAbs were used to compare the Bucyrus isolate of EAV and MAb neutralization-resistant (...

The replicase polyproteins of equine arteritis virus (EAV; family Arteriviridae, order Nidovirales) are processed by three viral proteases to yield 12 non-structural proteins (nsps). The nsp2 and nsp3 cleavage products have previously been found to interact, a property that allows nsp2 to act as a co-factor in the processing of the downstream part of the polyprotein by the nsp4 protease. Remark...