Primary brain tumors, particularly glioblastomas (GB), remain a challenge for oncology. An element of the malignant brain tumors' aggressive behavior is the fact that GB are among the most densely vascularized tumors. To determine some of the molecular regulations occuring at the brain tumor endothelium level during tumoral progression would be an asset in understanding brain tumor biology. Cav...

"To be human, means to be at play" (C.G. Jung). The democratisation of the east european societies caused an important development in the health system of these countries and in particular of mental health. Within the medicine itself, psychiatry as a special branch of it, is undergoing changes rapidly due to this important development in medicine. Relations of psychiatry with the rest of medici...

although childhood is connected with high neuroplasticity changes, but because of the immaturity of the neural and cognitive systems, it is ready to grow developmental deviations and future susceptibility for neuropsychological disorders. young children face cognitive, emotional, and linguistic limits that may lead them more vulnerable to post-traumatic stress disorder (ptsd). ptsd prevalence d...

Since around 1723, on the occasion of its initial colonization by Europeans, Rondonia has received successive waves of immigrants. This has been further swelled by individuals from northeastern Brazil, who began entering at the beginning of the twentieth century. The ethnic composition varies across the state according to the various sites of settlement of each wave of immigrants. We analyzed t...

Toll-like receptors (TLRs) are central sensors for the inflammatory response in ischemia-reperfusion injury. We therefore investigated whether TLR4 inhibition could be used to treat stroke in a standard model of focal cerebral ischemia. Anti-TLR4/MD2-antibody (mAb clone MTS510) blocked TLR4-induced cell activation in vitro, as reported previously. Here, different routes of MTS510 application in...

BACKGROUND Renal evaluation studies are rare in American Cutaneous Leishmaniasis (ACL). The aim of this study is to investigate whether specific treatment reverts ACL-associated renal dysfunction. METHODS A prospective study was conducted with 37 patients with ACL. Urinary concentrating and acidification ability was assessed before and after treatment with pentavalent antimonial. RESULTS Th...

Cephaloridine is a wide-spectrum antibiotic derived from cephalosporin and, despite similarities to penicillin, it can be used in the treament of infections in penicillin-sensitive patients. Riley, Boyle, and Leopold (I968) and Records (I969) have reported the intraocular penetration of cephaloridine into the aqueous after intramuscular and intravenous administration, and Moll, Crawford, and Mc...

Hypervigilance for pain-relevant stimuli has been associated with anxiety, fear of pain and anxiety sensitivity. This attentional bias has been primarily investigated in heterogeneous pain groups or pain-free controls, but has not been examined in pain conditions where anxiety and fear are likely to play a central role. Due to the intimate and interpersonal nature of genital pain experienced du...