Fall accidents are a significant problem for the elderly, in terms of both human suffering and economic losses. Localized muscle fatigue is a potential risk factor for slip-induced falls as muscle fatigue adversely affects proprioception, movement coordination and muscle reaction times leading to postural instability and gait changes. Specifically, fatigue in ankle is associated with decline in...

It has been well established that, in addition to the pulmonary involvement, COPD has systemic consequences that can lead to peripheral muscle dysfunction, with greater muscle fatigue, lower exercise tolerance and lower survival in these patients. In view of the negative repercussions of early muscle fatigue in COPD, the objective of this review was to discuss the principal findings in the lite...

In polycrystalline metals, local deformation heterogeneities induced by the microstructure influence fatigue crack initiation and micro-crack propagation. The localization in plastic strains associated with heterogeneous deformation has been described as a necessary condition and a precursor for the nucleation of fatigue cracks. However, a clear and quantitative assessment of the correlation be...

cerebral coenurosis is the intermediary larval stage of taenia multiceps , which affects intermediate hosts, particularly sheep and goats. in this report, gross and microscopic features of three scarce natural coenurosis cases, a oneyear-old ram and two lambs of 7 month old from a flock are explained. atnecropsy, numerous small cysts measuring 5 to 10 mm in diameter were observed on both cerebr...

OBJECTIVES 1) Estimate the prevalence of chronic disabling fatigue at age 13, and 2) investigate associations with early family adversity, using a population-based birth cohort study. METHODS The subjects were 10,001 children, of whom 5657 had sufficient data to define chronic disabling fatigue at age 13. Chronic disabling fatigue was defined as tiredness reported by mothers that had lasted f...

AIMS AND OBJECTIVES The purpose of this study was to examine the level of fatigue perceived by patients with heart failure and to explore the potential factors influencing fatigue. DESIGN A cross-sectional, correlational design was used. METHODS A convenience sample of 105 patients was recruited between July and September 2003 in northern Taiwan. The patients were interviewed, and their per...

A series of tests have been conducted to investigate fatigue damage characterization in corroded welded steel plates using structural health monitoring (SHM) techniques. Acoustic Emission (AE) is a non-destructive testing (NDT) technique with potential applications for locating and monitoring fatigue cracks in service. In the present work, AE is implemented to characterize damage during crack e...

The anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 controls progression to S phase and mitosis by stabilizing key APC/C ubiquitination substrates, including cyclin A. Examining Emi1 binding proteins, we identified the Evi5 oncogene as a regulator of Emi1 accumulation. Evi5 antagonizes SCF(betaTrCP)-dependent Emi1 ubiquitination and destruction by binding to a site adjacent to Emi1'...

BACKGROUND Fatigue damage of the long bones is prevalent in running athletes and military recruits due to vigorous mid- and long-term physical activity. The current study attempted to know the features of bony athletic fatigue damage and to explore the mechanism of fatigue damage repair through bone targeted remodeling process. METHODS Right ulnae of the Wistar rats were fatigue loaded on an ...