introduction breast cancer is one of the most life-threatening conditions among women. early detection of this disease is the only way to reduce the associated mortality rate. mammography is a standard method for the early detection of breast cancer. today, considering the importance of breast cancer detection, computer-aided detection techniques have been employed to increase the quality of ma...

how to cite this article: karimzadeh p. approach to neurometabolic diseases from a pediatric neurological point of view. iran j child neurol. 2015 winter;9(1): 1-16.   abstract objective neurometabolic disorders are an important group of diseases that mostly are presented in newborns and infants. neurological manifestations are the prominent signs and symptoms in this group of diseases. seizure...

how to cite this article: karimzadeh p, jafari n, alai mr, jabbehdari s, ahmad abadi f, nejadbiglari h. homocystinuria: diagnosis and neuroimaging findings - of iranian pediatric patients. iran j child neurol. 2015 winter;9(1):94-98. abstract objective homocystinuria is a neurometabolic diseases characterized by symptoms include neurodevelopmental delay, lens dislocation, long limbs and thrombo...

calcineurin (can) is a ca2+/calmodulin (ca2+/cam)-dependent serine/threonine protein phosphatase expressed in most mammalian tissues but found at higher concentration in brain. in the last decade there have been a steadily increasing number of studies identifying neuronal can as a primary suspect in neuronal vulnerability, synapse loss, dendritic atrophy, synaptic dysfunction and neuroinflammat...

breast cancer continues to be a significant public health problem in the world. early detection is the key for improving breast cancer prognosis. in this way, magnetic resonance imaging (mri) is emerging as a powerful tool for the detection of breast cancer. breast mri presently has two major challenges. first, its specificity is relatively poor, and it detects many false positives (fps). secon...

intoduction: the discovery of micrornas (mirnas), an extensive family of small non-protein-coding rnas, provided an exciting era in cancer research and recent findings have prompted us to revise the traditional concept of cancer. deregulated mirnas   expression influences biological events leading to cancer such as proliferation, differentiation, metastasis and apoptosis. the expression of onco...

Introduction: Lymphoscintigraphy is imaging of the lymphatic system and has been integrated into the sentinel node mapping procedures. Lymphoscintigraphy usually encompasses early or delayed static images. However, immediate dynamic imaging of the lymphatic basins and tumors has also been used as an adjunct lymphoscintigraphy imaging. The aim of this study was ...

Objective(s): The aim of this study was to analyze detection rates and effectiveness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) cancer screening program for prostate cancer in Japan, which is defined as a cancer-screening program for subjects without known cancer. It contains FDG-PET aimed at detection of cancer at an early stage with or without additional screening tests ...

breast carcinoma is the major cause of cancer-related death in women. the incidence of this carcinoma is rising and there are many attempts to decrease this problem. the aim of this study was detection of full-length cytokeratin 19 (ck19) mrna, in peripheral blood and tissue of breast cancer patients in early stage of cancer. in this study, rt-pcr (reverse transcriptase-polymerase chain reactio...