Background For the past 20 years, biologic (b)DMARDs have been main treatment option for children and young people with JIA where an initial conventional-synthetic DMARD has not effective. Since 2021, tofacitinib, a Janus Kinase (JAK) inhibitor become available of JIA. In phase 3 randomised controlled withdrawal design trial, tofacitinib demonstrated superior efficacy over placebo, although onl...

Early practical experience, based upon empirical observations strongly indicates that using classes as the basis for eeort estimation, can help to achieve DeMarco's holy grail. In providing evidence for this claim this position paper will describe (i) empirical size observations; (ii) estimations processes, based upon these observations ; and (iii) initial experiences using these processes. Thi...

Background Careful site selection methods and tools such as questionnaires have evolved to become “best” practice in the commercial and non-commercial clinical trials setting. However, there is little evidence in the literature of the value of such methodology on trial delivery and there is no generally acceptable model or tool available for use in site selection. The Nottingham Clinical Trials...

Introduction: Cardiac myxoma is a benign and rare tumor, which can present with a grim phenomenon if the presentation is late or the diagnosis and surgery are delayed. The purpose of this study was to share our institutional experience of cardiac myxoma. Material and Methods: This retrospective study was conducted to evaluate patients undergoing procedures at a single tertiary care centre for t...

introduction: although coronary endarterectomy is not an ideal procedure, it is the only available option for cardiac surgeons in some patients with diffuse coronary artery disease. based on the majority of conducted studies, the results of coronary endarterectomy (including survival, graft patency, and recurrence of the symptoms of myocardial ischemia) are less prevalent than standard coronary...