نتایج جستجو برای: e3

تعداد نتایج: 11331  

Journal: :Cell 2016
Daniel C. Scott David Y. Rhee David M. Duda Ian R. Kelsall Jennifer L. Olszewski Joao A. Paulo Annemieke de Jong Huib Ovaa Arno F. Alpi J. Wade Harper Brenda A. Schulman

Hundreds of human cullin-RING E3 ligases (CRLs) modify thousands of proteins with ubiquitin (UB) to achieve vast regulation. Current dogma posits that CRLs first catalyze UB transfer from an E2 to their client substrates and subsequent polyubiquitylation from various linkage-specific E2s. We report an alternative E3-E3 tagging cascade: many cellular NEDD8-modified CRLs associate with a mechanis...

Journal: :Discrete & Computational Geometry 2004
Egon Schulte

Chiral polyhedra in ordinary euclidean space E3 are nearly regular polyhedra; their geometric symmetry groups have two orbits on the flags, such that adjacent flags are in distinct orbits. This paper completely enumerates the discrete infinite chiral polyhedra in E3 with finite skew faces and finite skew vertex-figures. There are several families of such polyhedra of types {4, 6}, {6, 4} and {6...

2014
Shingo Suzuki Tsuyoshi Shuto Takashi Sato Masayuki Kaneko Tappei Takada Mary Ann Suico Douglas M. Cyr Hiroshi Suzuki Hirofumi Kai

N-glycosylation of proteins in endoplasmic reticulum is critical for protein quality control. We showed here a post-translational N-glycosylation affected by the HRD1 E3 ubiquitin ligase. Both WT- and E3-defective C329S-HRD1 decreased the level of high mannose form of ABCG8, a protein that heterodimerizes with ABCG5 to control sterol balance. Meanwhile, HRD1 increased the non-glycosylated ABCG8...

Journal: :Molecular biology of the cell 1995
V Sudakin D Ganoth A Dahan H Heller J Hershko F C Luca J V Ruderman A Hershko

The ubiquitin-mediated degradation of mitotic cyclins is required for cells to exit from mitosis. Previous work with cell-free systems has revealed four components required for cyclin-ubiquitin ligation and proteolysis: a nonspecific ubiquitin-activating enzyme E1, a soluble fraction containing a ubiquitin carrier protein activity called E2-C, a crude particulate fraction containing a ubiquitin...

Journal: :Journal of immunology 2011
Magdalena Paolino Christine B F Thien Thomas Gruber Reinhard Hinterleitner Gottfried Baier Wallace Y Langdon Josef M Penninger

E3 ubiquitin ligases have been placed among the essential molecules involved in the regulation of T cell functions and T cell tolerance. However, it has never been experimentally proven in vivo whether these functions indeed depend on the catalytic E3 ligase activity. The Casitas B-cell lymphoma (Cbl) family protein Cbl-b was the first E3 ubiquitin ligase directly implicated in the activation a...

Journal: :The Journal of general virology 1992
S K Mittal L Prevec L A Babiuk F L Graham

The DNA sequences of the early region 3 (E3) and fibre protein genes of bovine adenovirus type 3 (BAd3) have been determined and the amino acid sequences predicted to be encoded by their open reading frames (ORFs) compared to those of the fibre and E3 proteins from other Ads. One of the BAd3-E3 proteins contains a region homologous to the 14.7K E3 protein of human Ad5 (HAd5). The putative BAd3 ...

Journal: :American journal of physiology. Endocrinology and metabolism 2015
Noriko Yamabe Ki Sung Kang Woojung Lee Su-Nam Kim Bao Ting Zhu

Despite increased total food intake in healthy, late-stage pregnant women, their peak postprandial blood sugar levels are normally much lower than the levels seen in healthy nonpregnant women. In this study, we sought to determine whether estriol (E3), an endogenous estrogen predominantly produced during human pregnancy, contributes to the regulation of the postprandial blood glucose level in h...

2014
Woo Seok Yang Jaeyoung Ko Eunji Kim Ji Hye Kim Jae Gwang Park Nak Yoon Sung Han Gyung Kim Sungjae Yang Ho Sik Rho Yong Deog Hong Song Seok Shin Jae Youl Cho

21-O-Angeloyltheasapogenol E3 (ATS-E3) is a triterpenoid saponin recently isolated from the seeds of the tea tree Camellia sinensis (L.) O. Kuntze. ATS-E3 has several beneficial properties including anti-inflammatory, antidiabetic, antiatherosclerotic, and anticancer effects. Unlike other phenolic compounds isolated from tea plants, there are no studies reporting the pharmacological action of A...

Journal: :The American journal of physiology 1999
C D Mamotte M Sturm J I Foo F M van Bockxmeer R R Taylor

Compared with apolipoprotein E3 (apoE3), apoE2 is less effective in mediating the binding of lipoproteins to the low-density lipoprotein (LDL) receptor. The influence of the E4 isoform, which is associated with adverse effects on plasma lipids and coronary heart disease, is less clear. We compared the ability of very low density lipoprotein (VLDL) and LDL from paired E4/4 and E3/3 subjects to c...

Journal: :The Plant cell 2002
Claus Schwechheimer Giovanna Serino Xing-Wang Deng

The COP9 signalosome (CSN) is an evolutionarily conserved multiprotein complex that mediates the repression of photomorphogenesis in the dark in Arabidopsis through the degradation of transcription factors such as HY5 and HYH. CSN-mediated HY5 and HYH degradation also requires the activity of the putative E3 ubiquitin ligase (E3) component COP1 and the E2-conjugating enzyme variant COP10. Recen...

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