نتایج جستجو برای: dystonic disorders
تعداد نتایج: 671738 فیلتر نتایج به سال:
Dystonias are movement disorders whose pathomechanism is largely unknown. The dt dystonic hamster mutant represents a model of primary paroxysmal dystonia, where alterations of striatal interneuron density and long term potentiation were described (Köhling et al., 2004, Gernert et al., 2000). In the present thesis, using corticostriatal slices, we explore in more detail whether long-term potent...
The suspicion of a diagnosis of Rett syndrome (RTT) is based on clinical criteria that are often not present in the first two stages of the disease, as many of its symptoms will appear at a later age. This sometimes postpones the genetic diagnosis and an early clinical intervention. We present the case of 19-months-old girl who came to the consultation because of an arrest of psychomotor develo...
INTRODUCTION Tremor is frequently associated with dystonia, but its pathophysiology is still unclear. Dysfunctions of cerebellar circuits are known to play a role in the pathophysiology of action-induced tremors, and cerebellar impairment has frequently been associated to dystonia. However, a link between dystonic tremor and cerebellar abnormalities has not been demonstrated so far. METHODS T...
Dystonia is a neurological disorder characterized by excessive involuntary muscle contractions that lead to twisting movements. The exaggerated movements have been studied and have implicated basal ganglia as the point of origin. In more recent studies, the cerebellum has also been identified as the possible target of dystonia, in the search for alternative treatments. Tiagabine is a selective ...
A broader palette of safe and better-tolerated agents is available for treating people suffering from chronic schizophrenia, depressive disorders, anxiety disorder, autism spectrum disorders. However, current medical treatments are still only partially effective, and highly-prevalent psychiatric disorders continue to represent a huge personal and socio-economic burden. Most pharmacological agen...
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