Loss of expression for both the estrogen receptor-alpha and E-cadherin genes has been linked to disease progression in human ductal breast carcinomas and has been associated with aberrant 5' CpG island methylation. To assess when, during malignant progression, such methylation begins and whether such methylation increases with advancing disease, we have surveyed 111 ductal carcinomas of the bre...

Background & Objective: Ki-67 evaluation is an essential tool to define luminal A and B breast cancers, which is not yet systematized. The International Ki67 in Breast Cancer Working Group suggests the counting of 500 or 1000 cancer cells, which is a time-consuming process. Therefore, novel methods, such as the Eye-10 method and stepwise counting strategy, are proposed to facil...

Pulmonary hypertension may occur in the fetus in the presence of constriction of the ductus arteriosus. The feasibility of detection and quantitation of fetal ductal constriction by Doppler echocardiography was assessed in an animal preparation in which ductal constriction was created in the fetal lamb with a variable ligature causing varying degrees of fetal pulmonary hypertension (fetal pulmo...

Before the era of mammography, ductal carcinoma in situ (DCIS) comprised only less than 3% of newly diagnosed breast cancers, most as large palpable masses, and many with microscopic foci of invasion. With widespread use of mammography, DCIS now makes up about 25% of breast cancers diagnosed in the U.S., most as non-palpable lesions. There is also concurrent increased prevalence of atypical duc...

BACKGROUND There is a strong need to define the molecular changes in normal at-risk breast epithelium to identify biomarkers and new targets for breast cancer prevention and to develop a molecular signature for risk assessment. Improved methods of breast epithelial sampling are needed to promote whole-genome molecular profiling, increase ductal epithelial cell yield, and reduce sample cell hete...

OBJECTIVE To correlate the different non masslike enhancement categories detected by Magnetic Resonance Imaging (MRI) and the corresponding histological findings. PATIENTS AND METHODS Two experienced radiologists reviewed the MRI examinations of 94 patients presenting non mass-like enhancements who had performed histological evaluation. According to the BI-RADS (Breast Imaging Reporting and D...

Sialography is the retrograde injection of an iodinated contrast agent into the ductal system of salivary glands and this technique is the only method capable of adequately demonstrating the status of the ductal system. One of the indications of sialography is classification of the salivary ductal system fistulae. This classification has important prognostic and therapeutic values. In the prese...

Ductal adenocarcinoma is an unusual variant of adenocarcinoma of the prostate. A 73-year-old male was referred to our hospital for the further examination of an elevated prostate-specific antigen level of 23.4 ng/mL. Radical prostatectomy (RP) was performed based on the diagnosis obtained by a prostate needle biopsy. The RP specimen revealed ductal adenocarcinoma of the prostate with positive c...

congenital hepatic fibrosis (chf) is a developmental disorder of the biliary system, characterized by defective remodeling of the ductal plate. herein a family of three children, from consanguineous parents, with minor thalassemia is presented who suffered from congenital hepatic fibrosis (chf). prompt diagnosis and appropriate treatment are necessary to avoid further complications in the affec...

objective: to review her-2/neu and tp53 status and their correlation with all other prognostic clinicopathologic features of infiltrative ductal breast carcinomas. materials and methods: this cross sectional study was performed on 139 patients with infiltrative ductal breast carcinoma who were diagnosed between may 2000 and march 2006 at the surgery and pathology departments of alzahra hospital...