نتایج جستجو برای: dtnbp1

تعداد نتایج: 174  

Journal: :Archives of general psychiatry 2004
Cynthia Shannon Weickert Richard E Straub Benjamin W McClintock Mitsuyuki Matsumoto Ryota Hashimoto Thomas M Hyde Mary M Herman Daniel R Weinberger Joel E Kleinman

CONTEXT The schizophrenia-susceptibility gene dysbindin (DTNBP1 on 6p22.3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain. OBJECTIVES To determine whether brain regions implicated in schizophrenia express dysbindin and whether abnormal levels of dysbindin ...

2016
Deniz Cizmeci Emma L. Dempster Olivia L. Champion Sariqa Wagley Ozgur E. Akman Joann L. Prior Orkun S. Soyer Jonathan Mill Richard W. Titball

The potential for epigenetic changes in host cells following microbial infection has been widely suggested, but few examples have been reported. We assessed genome-wide patterns of DNA methylation in human macrophage-like U937 cells following infection with Burkholderia pseudomallei, an intracellular bacterial pathogen and the causative agent of human melioidosis. Our analyses revealed signific...

Journal: :The Journal of clinical investigation 2004
Konrad Talbot Wess L Eidem Caroline L Tinsley Matthew A Benson Edward W Thompson Rachel J Smith Chang-Gyu Hahn Steven J Siegel John Q Trojanowski Raquel E Gur Derek J Blake Steven E Arnold

Eleven studies now report significant associations between schizophrenia and certain haplotypes of single-nucleotide polymorphisms in the gene encoding dysbindin-1 at 6p22.3. Dysbindin-1 is best known as dystrobrevin-binding protein 1 (DTNBP1) and may thus be associated with the dystrophin glycoprotein complex found at certain postsynaptic sites in the brain. Contrary to expectations, however, ...

Journal: :Cancer research 2009
Tong Xie Thuyen Nguyen Melanie Hupe Maria L Wei

Whereas resistance to chemotherapy has long impeded effective treatment of metastatic melanoma, the mechanistic basis of this resistance remains unknown. One possible mechanism of drug resistance is alteration of intracellular drug distribution either by drug efflux or sequestration into intracellular organelles. Melanomas, as well as primary melanocytes from which they arise, have intracellula...

2014
Meng-Hsuan J. Han Zhonghua Hu Cai Yun Chen Yong Chen Marjan Gucek Zheng Li Sanford P. Markey

The gene DTNBP1 encodes the protein dysbindin and is among the most promising and highly investigated schizophrenia-risk genes. Accumulating evidence suggests that dysbindin plays an important role in the regulation of neuroplasticity. Dysbindin was reported to be a stable component of BLOC-1 complex in the cytosol. However, little is known about the endogenous dysbindin-containing complex in t...

2010
Hiroaki Okuda Ryusuke Kuwahara Shinsuke Matsuzaki Shingo Miyata Natsuko Kumamoto Tsuyoshi Hattori Shoko Shimizu Kohei Yamada Keisuke Kawamoto Ryota Hashimoto Masatoshi Takeda Taiichi Katayama Masaya Tohyama

BACKGROUND An accumulating body of evidence suggests that Dtnbp1 (Dysbindin) is a key susceptibility gene for schizophrenia. Using the yeast-two-hybrid screening system, we examined the candidate proteins interacting with Dysbindin and revealed one of these candidates to be the transcription factor NF-YB. METHODS We employed an immunoprecipitation (IP) assay to demonstrate the Dysbindin-NF-YB...

Journal: :Biocell 2022

Hepatocellular carcinoma (HCC) is a common immunogenic malignant tumor. Although the new strategies of immunotherapy and targeted therapy have made considerable progress in treatment HCC, 5-year survival rate patients still very low. The identification prognostic signatures exploration immune microenvironment are crucial to optimization improvement molecular strategies. We studied potential cli...

2003
Michael C. O’Donovan Nigel M. Williams Michael J. Owen

The high heritability of schizophrenia has stimulated much work aimed at identifying susceptibility genes using positional genetics. As a result, several strong and well-established linkages have emerged. Three of the best-supported regions are 6p24–22, 1q21–22 and 13q32–34 where single studies have achieved genomewide significance at P< 0.05 and suggestive positive findings have also been repo...

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