The large-conductance voltage- and Ca(2+)-activated K(+) (BK) channel is expressed in many smooth muscle types, but its role in human detrusor smooth muscle (DSM) is unclear. With a multidisciplinary approach spanning channel molecules, single-channel activity, freshly isolated human DSM cells, intact DSM preparations, and the BK channel specific inhibitor iberiotoxin, we elucidated human DSM B...

Diagnostic and Statistical Manual (DSM-5) criteria for ASD have been criticized for being too restrictive, especially for more cognitively-able individuals. It is unclear, however, if high-functioning individuals deemed eligible for research via standardized diagnostic assessments would meet DSM-5 criteria. This study investigated the impact of DSM-5 on the diagnostic status of 498 high-functio...

Since the first edition of the Diagnostic and Statistical Manual: Mental Disorders was published in 1952 by the American Psychiatric Association (APA), the manual has gone through a series of revisions: DSM-II in 1968, DSM-III in 1980, DSM-IIIR in 1987, DSM-IV in 1994, and a text revision to the DSM-IV in 2000. For those with a sharp eye, one will note that, subsequent to DSM-I, the manual has ...

This paper presents the design and implementation issues for the use of DSM techniques to allow shared access to objects in an object-oriented distributed environment. J-DSM supports sharing of Java objects, thus allowing a finer control over the granularity of sharing. J-DSM elaborates on two main classes of shared objects, mobile and stationary, which can be accessed through DSM and RMI mecha...

This paper aims to interpret Demand-Side Management (DSM) activity and to point out its problems, adopting micro economics as an analytical tool. Two major findings follow. First, the cost-benefit analysis currently in use has the following problems: (i) inconsistency in cost comparison between utility costs on the supply-side and utility costs plus customer costs on the demand-side, (ii) incon...

BACKGROUND Compared to DSM-IV, the criteria for diagnosing posttraumatic stress disorder (PTSD) have been modified in DSM-5. OBJECTIVE The first aim of this study was to examine how these modifications impact rates of PTSD in a sample of Congolese ex-combatants. The second goal of this study was to investigate whether PTSD symptoms were associated with perpetrator-related acts or victim-relat...

Hristov KL, Smith AC, Parajuli SP, Malysz J, Petkov GV. Large-conductance voltageand Ca -activated K channel regulation by protein kinase C in guinea pig urinary bladder smooth muscle. Am J Physiol Cell Physiol 306: C460–C470, 2014. First published December 18, 2013; doi:10.1152/ajpcell.00325.2013.—Large-conductance voltageand Ca -activated K (BK) channels are critical regulators of detrusor sm...