INTRODUCTION: Dynamic susceptibility contrast MRI (DSC-MRI) is a novel tool that has shown promise to increase the predictive power of diagnostic imaging, for example in the assessment of brain tumor grade [1]. Alterations in microvascular parameters such as blood volume and vascular permeability induced by pathological angiogenesis are detectable with DSC-MRI. However, the basic assumptions of...

The ability of stem cells to self-renew as well as their multilineage differentiation potential makes them ideal candidates for skin regeneration strategies. Mesenchymal stem cells residing in human adult dermis, in contrast to adipose tissue, have not yet been described. The objective of this study was to determine the stemness and chemokine-mediated homing potential of dermal stromal cells (D...

OBJECTIVE The added value of perfusion MRI for decision-making in vestibular schwannoma (VS) patients is unknown. MRI offers two perfusion methods: the first employing contrast agent (dynamic susceptibility contrast (DSC)-MRI) that provides information on cerebral blood volume (CBV) and cerebral blood flow (CBF), the second by magnetic labeling of blood (arterial spin labeling (ASL)-MRI), provi...

Many video compression schemes (e.g., the recent H.264/AVC standard) and volumetric image coding algorithms are based on a closed-loop prediction (CLP) framework. While CLP based schemes can achieve state-of-the-art coding efficiency, they are inadequate in addressing some important emerging applications such as wireless video, multiview video, etc, which have new requirements including low com...

Laboratory measurements on polymer raw materials and products are often carried out (quasi-) isothermally, or at best at relatively slow cooling and heating rates. Such conditions differ greatly from those occurring during processing and during the product’s use in real life. During processing, high cooling rates and high pressures are common, the parameters of which have a major influence on t...

BACKGROUND AND PURPOSE The usefulness of arterial spin-labeling for the evaluation of the effect of the antiangiogenic therapy has not been elucidated. Our aim was to evaluate the antiangiogenic effect of bevacizumab in a rat glioblastoma model based on arterial spin-labeling perfusion MR imaging. MATERIALS AND METHODS DSC and arterial spin-labeling perfusion MR imaging were performed by usin...

OBJECTIVES This work deals with the conformational and thermal characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin by the matrix metalloproteinase-12 that was shown to form amyloid-like fibres under certain conditions. MATERIALS AND METHODS S4 peptides were synthesized by solid-phase methodology and aggregated in solution at 80°C. Fourier transfo...

BACKGROUND This study was to elucidate the psychometric properties of the Korean version of the Diabetes Symptom Checklist-Revised (K-DSC-R), which is a patient-reported outcome measure of diabetes symptom burden. METHODS A sample of 432 Korean patients with diabetes was recruited from university hospitals. The data were analyzed using exploratory factor analysis (EFA), confirmatory factor an...

We have previously reported that the danshensu-cysteine conjugate N-((R)-3-benzylthio-1-methoxy-1-oxo-2-propanyl)-2-acetoxy-3-(3,4-diacetoxyphenyl) propanamide (DSC) is a potent anti-oxidative and anti-apoptotic agent. Herein, we further design and asymmetrically synthesize two diastereoisomers of DSC and explore their potential bioactivities. Our results show that DSC and its two diastereoisom...

Mesenchymal stromal cells (MSCs) are increasingly used in regenerate medicine. Placenta-derived decidual stromal cells (DSCs) are a novel therapy for acute graft-versus-host-disease (GVHD) and hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT). DSCs are more immunosuppressive than MSCs. We assessed adverse events and safety using DSCs among 44 treated pati...