نتایج جستجو برای: drug toxicity
تعداد نتایج: 637719 فیلتر نتایج به سال:
In clinical trials, pharmaceutical companies test the efficacy and safety of a new drug for the treatment of a disease by comparing the results from a large number of diseased and healthy patients exposed to either the new drug, an existing drug that treats the disease, or a placebo. One primary concern is liver toxicity, which is usually diagnosed by blood analyte tests. Often, such signals of...
Drug interactions can occur when two or more medications are simultaneously given, and one drug increases decreases the effectiveness of other. Azole antifungal agents show a wide range with other drugs. Failure to recognize drug–drug interaction may produce harm patient, including enhanced toxicity concomitantly administered medication. Most azole antifungals pharmacokinetic type. This article...
Adverse drug reactions (ADRs) continue to be a significant contributor to overall attrition statistics in the pharmaceutical industry. ADRs pose a significant health problem since they contribute to patient morbidity and mortality and represent one of the most common causes for pharmaceutical product recalls and black-box warning labels. Of a total of 548 drugs approved in the period from 1975 ...
Therapeutic drugs and chemicals used in our bodies or in our environment must be guaranteed safe to the people who are exposed to them. Extensive procedures for screening and predicting toxicity have been developed in the pharmaceutical industry. Nevertheless, drugs that are toxic to some subset of the population are not always identified by these procedures. About 30% of drug development failu...
A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoin...
Contemporary information on road salt runoff is needed for management of water resources in regions experiencing urbanization and increased road density. We investigated seasonal Cl(-) concentrations among five streams in south-central Indiana that drained watersheds varying in degree of urbanization and ranging in size from 9.3 to 27 km(2). We also conducted acute toxicity tests with Daphnia p...
Sediment toxicity tests are valuable tools for assessing the potential effects of contaminated sediments in dredged material evaluations because they inherently address complexity (e.g., unknown contaminants, mixtures, bioavailability). Although there is a need to understand the chronic and sublethal impacts of contaminants, it is common to conduct only short-term lethality tests in evaluations...
As cancer growth and development typically involves multiple genes and pathways, combination therapy has been touted as the standard of care in the treatment of cancer. However, drug toxicity becomes a major concern whenever a patient takes 2 or more drugs simultaneously at the maximum tolerable dosage. A potential solution would be administering the drugs in a sequential or alternating manner ...
The Toxic Substances Control Act is the principal US law governing industrial chemicals. Over the past three and one half decades, it has become clear that a considerable toxicological information gap exists about chemicals in commerce. The current provisions of the US TSCA law have failed to fill, and perhaps even exacerbated, that gap. For at least the past 5 years, bills have been introduced...
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