We analyzed 57 publications devoted to study of genetic mechanisms formation drug resistance Mycobacterium tuberculosis bedaquiline, delamanid, pretomanid, linezolid, and clofazimine. Identification factors MTB make the basis search for new targets in development anti-tuberculosis drugs methods susceptibility testing.

The drug susceptibility of 3 isoenzymic strains of Trypanosoma cruzi was studied. Two drugs (SQ 18, 506 and Ro 7-1051) and 6 stocks were used. The drug test was carried out on epimastigote cultures. Significant susceptibility differences were found for Ro 7-1051 between the 3 strains. For SQ 18, 506, there were differences between strains 1 and 2, and 2 and 3, but no differences between 1 and 3...

PURPOSE To compare the rapid colorimetric nitrate reductase based antibiotic susceptibility (CONRAS) test performed on Mycobacterium tuberculosis isolates with the conventional method i.e, the proportion method. METHODS One hundred clinical isolates of M. tuberculosis were tested for susceptibility to isoniazid (INH) and rifampicin (RIF) by the conventional proportion method and CONRAS in Mid...

Delays in Identification of M tuberculosis The CDC recently reported the mycobacteriology laboratory practices of 2,862 laboratories that are enrolled in federally approved proficiency testing (PT) programs. Enrollment in these PT programs is required by the 1988 Clinical Laboratory Improvement Amendments (CLIA). Of the 2,862 laboratories, 2,179 reported performing primary culture for Mycobacte...

A total of 385 urine specimens from suspected urinary tract infections were subjected to bacteriological analysis and susceptibility testing at a major university hospital laboratory in Tehran. A battery of eight beta-Iactam antibiotics, commonly prescribed in Iran, and three third-generation cephalosporins (ceftazidime, ceftriaxone and ceftizoxime) that are usually reserved for limited us...

conclusions it was the first study that attempted to detect the insertion elements isaba and ic lineages in mdr-ab species isolated from patients with burning in iran. background multidrug resistant strains of acinetobacter baumannii (mdr-ab) have emerged as alarming nosocomial pathogens among patients with burning. objectives the current study aimed to determine the susceptibility of a. bauman...

A simple technique for routine, reproducible global surveillance of the drug susceptibility status of the anaerobic protozoa Trichomonas, Entamoeba, and Giardia is described. Data collected using this technique can be readily compared among different laboratories and with previously reported data. The technique employs a commercially available sachet and bag system to generate a low-oxygen envi...

Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients.