Associated with the old/traditional of method drug delivery are several limitation ranging from first-pass effect, low tolerance, minimal bioavailability, fluctuation plasma concentration which result to less or no desired effect produced. This call for demand a more efficient administration technique. Lipid systems biocompatible, inert and biodegradable, stable deliver at target effect. paper ...

The loading and containment of cargo within nanoparticles and their efficient delivery to cells represent a primary challenge in nanomedicine. We report lipid exchange between free and mesoporous silica nanoparticle-supported lipid bilayers as an effective means of containing cargo, controlling charge, and directing delivery to mammalian cells. The delivery of a membrane-impermeable dye (calcei...

The investigation of the intermolecular interactions between platinum-based anticancer drugs and lipid bilayers is special relevance to unveil mechanisms involved in different steps mode action these drugs. We have simulated permeation cisplatin through a model membrane composed 1,2-dioleoyl-sn-glycero-3-phosphocholine lipids by means umbrella sampling classical molecular dynamics simulations. ...

PURPOSE Lipid suspensions as drug carriers, including conventional liposomes, ethosomes, transferosomes, proniosomes, niosomes, PEG-PPG-PEG niosomes and stratum corneum liposomes (cerosomes), were formulated and compared. METHODS Lipid vesicles were formulated and assessed with regards to enhancement of skin permeation of diclofenac and stability profiles of the formulations. Formulation-indu...

Hot-melt coating process (HMCP) was applied to develop a lipid based oral controlled release matrix system (tablet) to deliver highly aqueous soluble drugs using paracetamol as a model drug. Granules prepared from paracetamol and particular filler were coated with different levels of lipid and then compressed into tablets to get controlled/sustained delivery of the drug over an optimum period. ...

Abstract: Background: The aim of present study was to carry out the formulation design and evaluation Solid Lipid Nanoparticles (SLNs) loaded topical gel Flurbiprofen. Materials Methods: Flurbiprofen solid lipid nanoparticles were formulated using Glyceryl monostearate (GMS) as matrix by solvent evaporation method followed probe sonication. A 32 full factorial utilized optimize SLNs. Drug: rati...