In the evolution of AIE-based drug and gene delivery systems, light-up AIEgens start in real-time monitoring processes evaluation therapeutic responses drug/gene; The delicate structural design to form high-level carriers remarkably enhances drug/gene efficiency; Further, endowed with multifunctionalities, are synergized multimodality therapy achieve augmented efficiency(e282).

Abstract AIMS Synergistic combinations of doxorubicin and gemcitabine have been assessed for post-surgical treatment IDH1 wild-type glioblastoma (GBM). As a complementary drug carrier, hyperbranched micellar nanoparticles are being investigated to enable enhanced loading sustained release. METHOD 2D 3D spheroid in vitro models generated from patient-derived cells resected tumour core invasive m...

Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-...

In this study, the combination of Phenergan C17H2ON2S, in which two aromatic rings are present, are attached to the rings at carbon position 5 and 13 halogens, and the changes in the asymmetric parameter, the convex constants, and the chemical displacement of the lateral carbon atoms are calculated. It shows that with the change of halogen based on the electrone...