Introduction: Curcumin, a BCS II drug, suffers from poor bioavailability. Increasing curcumin dissolution is way to increase its Solid dispersion formulation can be used improve dissolution. However, the successful solid limited relatively low drug load (< 20%). Aim: This study aimed investigate behaviour of at higher (27.9%, 42.3%, and 56.6%) using surfactant carrier poloxamer 407. Methods:...

5-Fluorouracil (5-FU) is an anticancer drug. In this work, we have investigated the electronic properties and topological analysis of interaction between 5-FU and carbon nanocone and BN nanocone. The structural stability of isomer complexes of 5-FU with carbon nanocone and BN nanocone have been investigated for two position of interactions. We have found that the most stable complexes are forme...

PURPOSE The purpose of this study was to prepare and characterize solid dispersion formulation of furosemide to enhance dissolution rate. METHODS Solid dispersions with different drug: carrier ratios were prepared by cogrinding method using crospovidone and microcrystalline cellulose as carrier. The physical state and interactions between the drug and carrier were characterized by Fourier tra...

The present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. SBA-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (MPTS). The parent and thiol-functionalized SBA-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). The charac...

This work presents tools for estimating Fine Particle Fractions generated inside Dry Powder Inhalers, by analysing detachment of drug particles from carrier particles. The trajectories of carrier particles through an inhaler are simulated using the FLUENT software for Computational Fluid Dynamics. These are analysed, by evaluating the forces that may break carrier/drug bonds. These forces, from...

The novel carriers have been exploited through almost all the routes of administration. Association of drugs with carriers is normally noncovalent, based on collective strength of weak binding forces. Many newer carriers are evolving with the advent of technology and the demand of targeted delivery like microemulsions. Microemulsions are clear, stable, isotropic mixtures of oil, water and surfa...

Ebastine (EBS) is a non-sedating antihistamine with long duration of action. This drug has predominantly hydrophobic property causing low solubility and bioavailability. Surface solid dispersions (SSD) an effective technique for improving the dissolution rate poorly soluble drugs by using hydrophilic water insoluble carriers.
 The present study aims to enhance EBS surface dispersion techni...