results the results showed that there was a significant difference between age, marital status, drug type used and length of abstinence with domains of qol (p = 0.001). conclusions the findings of the current study show that consistent participation in na self-help groups can significantly lead to an increase in qol. further research is recommended to find out causal relationships between parti...

In accordance with the chronic disease model of opioid dependence, cessation is often observed as a longitudinal process rather than a discrete endpoint. We aimed to characterize and identify predictors of periods of heroin abstinence in the natural history of recovery from opioid dependence. Data were collected on participants from California who were enrolled in the Civil Addict Program from ...

OBJECTIVE To understand better the relationship between substance-use disorder treatment and abstinence self-efficacy, more information is needed about what factors predict greater abstinence self-efficacy. METHOD Participants (n = 2,350) from 88 community residential facilities were assessed at treatment entry and 1-year follow-up. Treatment providers reported on patients' engagement in spec...

In accordance with the chronic disease model of opioid dependence, cessation is often observed as a longitudinal process rather than a discrete endpoint. We aimed to characterize and identify predictors of periods of heroin abstinence in the natural history of recovery from opioid dependence. Data were collected on participants from California who were enrolled in the Civil Addict Program from ...

Perineuronal Nets (PNNs) are specialized extracellular matrix structures of the brain that are found around specific neurons. PNNs play a role in structural and developmental plasticity, it remains unknown how they are affected by drugs of addiction. In the US, drug use has a very profound impact medically, economically, and socially. We used a conflict model which mimicked human drug seeking b...

Individuals approved for public-sector addiction treatment were interviewed regarding their reasons for attempting abstinence. Follow-up interviews were completed 3 to 6 months after participants' removal from county-controlled treatment wait-lists. Rates of continuous self-reported abstinence for 90 days preceding follow-up were positively associated with motivation linked to discrepancies bet...

objective: the present study was conducted to compare the effectiveness of two therapeutic approaches, namely, cognitive behavioral therapy (cbt) and stages of change model (soc) on improving abstinence self-efficacy in adolescent addicts. methods: forty five self-referred adolescent addicts were randomly selected to take part in this study. initial assessment was made using the following quest...

Social partners influence the likelihood of using drugs, developing a substance use disorder and relapse to drug use after a period of abstinence. Preclinical studies report that social cues influence the acquisition of cocaine use, the escalation of cocaine use over time, and the compulsive patterns of cocaine use that emerge during an extended binge. The purpose of this study was to examine t...

Adult-generated neurons in the dentate gyrus (DG) of the hippocampus play a role in various forms of learning and memory. However, adult born neurons in the DG, while still at an immature stage, exhibit unique electrophysiological properties and are also functionally implicated in learning and memory processes. We investigated the effects of extinction of drug-seeking behavior on the formation ...