نتایج جستجو برای: drosha

تعداد نتایج: 598  

2015
Jana Obsteter Peter Dovc Tanja Kunej

MicroRNAs are currently being extensively studied due to their important role as post-transcriptional regulators. During miRNA biogenesis, precursors undergo two cleavage steps performed by Drosha-DGCR8 (Microprocessor) cleaving of pri-miRNA to produce pre-miRNA and Dicer-mediated cleaving to create mature miRNA. Genetic variants within human miRNA regulome have been shown to influence miRNA ex...

2018
Jung Oh Kim Jinkun Bae Jinkwon Kim Seung Hun Oh Hui Jeong An In Bo Han Doyeun Oh Ok Joon Kim Nam Keun Kim

BACKGROUND AND PURPOSE MicroRNA (miRNA) expression has been examined in multiple conditions, including various cancers, neurological diseases, and cerebrovascular diseases, particularly stroke. Existing evidence indicates that miRNA biosynthesis and function play crucial roles in ischemic stroke physiology and pathology. In this study, we selected six known polymorphisms in miRNA-biogenesis gen...

Journal: :Cold Spring Harbor symposia on quantitative biology 2006
Y Lee J Han K-H Yeom H Jin V N Kim

MicroRNA (miRNA)-mediated gene silencing is one of the major regulatory pathways in eukaryotes. Much effort has been made to identify the factors involved in the pathway, and our understanding of RNA silencing has significantly advanced in recent years. Our group has been working on some of the issues regarding miRNA biogenesis and, in this paper, we summarize what we and other workers in the f...

Journal: :Current Biology 2005
Yukihide Tomari Phillip D. Zamore

The ribonuclease Drosha requires a dedicated double-stranded RNA binding protein to convert long, nuclear primary microRNA transcripts into shorter pre-microRNA stem-loops, the cytoplasmic precursors from which mature microRNAs are ultimately excised.

Journal: :Molecular cell 2015
Jenna L Jewell Fabian Flores Kun-Liang Guan

In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Sara H Weitz Ming Gong Ian Barr Shimon Weiss Feng Guo

DiGeorge syndrome critical region gene 8 (DGCR8) is the RNA-binding partner protein of the nuclease Drosha. DGCR8 and Drosha recognize and cleave primary transcripts of microRNAs (pri-miRNAs) in the maturation of canonical microRNAs (miRNAs) in animals. We previously reported that human, frog, and starfish DGCR8 bind heme when expressed in Escherichia coli and that Fe(III) heme activates apoDGC...

2016
Natalia Simionescu Loredan S. Niculescu Mihaela G. Carnuta Gabriela M. Sanda Camelia S. Stancu Andreea C. Popescu Mihaela R. Popescu Adelina Vlad Doina R. Dimulescu Maya Simionescu Anca V. Sima

We aimed to determine the levels of microRNAs (miRNAs) in sera and HDL of acute coronary syndrome (ACS) compared to stable angina (SA) patients with/without hyperglycemia, and evaluate comparatively the functional effect of these sera on the processing machinery proteins (Drosha, DGCR8, Dicer) and miRNAs production in human macrophages. MiRNAs levels in sera and HDL from 35 SA and 72 ACS patien...

2011
Maja M. Janas Mehdi Khaled Steffen Schubert Jacob G. Bernstein David Golan Rosa A. Veguilla David E. Fisher Noam Shomron Carmit Levy Carl D. Novina

The majority of mammalian microRNA (miRNA) genes reside within introns of protein-encoding and non-coding genes, yet the mechanisms coordinating primary transcript processing into both mature miRNA and spliced mRNA are poorly understood. Analysis of melanoma invasion suppressor miR-211 expressed from intron 6 of melastatin revealed that microprocessing of miR-211 promotes splicing of the exon 6...

Journal: :Molecular cell 2015
Sara Macias Ross A Cordiner Philippe Gautier Mireya Plass Javier F Cáceres

The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of particular interest, DGCR8 controls the stability of mature small nucleolar RNA (snoRNA) transcripts independently of Drosha, suggesting the existence of alternative DGCR8 complex(es) with other nucleases to process a variety of c...

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