نتایج جستجو برای: drb3 alleles
تعداد نتایج: 67674 فیلتر نتایج به سال:
Mastitis of cows causes significant harm to dairy farming, a susceptibility which is partly determined by genetic factors. Therefore, identifying the or resistance mastitis at an early stage postnatal ontogenesis has both practical and scientific importance. In this work, we examined model grounded on collegial use lymphocyte antigens class I MHC cattle DNA markers based alleles BoLA-DRB3 gene ...
Assessing donor/recipient HLA compatibility at the eplet level requires second field DNA typings but these are not always available. These can be estimated from lower‐resolution data either manually or with computational tools currently relying, best, on containing typing ambiguities. We gathered NGS 61,393 individuals in 17 French laboratories, for loci A, B, and C (100% of typings), DRB1 DQB1...
The human leukocyte antigen (HLA) class I and class II loci are the most polymorphic genes in the human genome. Hematopoietic stem cell transplantation requires allele-level HLA typing at multiple loci to select the best matched unrelated donors for recipient patients. In current methods for HLA typing, both alleles of a heterozygote are amplified and typed or sequenced simultaneously, often ma...
Statistical imputation of classical HLA alleles in case-control studies has become established as a valuable tool for identifying and fine-mapping signals of disease association in the MHC. Imputation into diverse populations has, however, remained challenging, mainly because of the additional haplotypic heterogeneity introduced by combining reference panels of different sources. We present an ...
زمینه مطالعه: مجتمع اصلی سازگاری نسجی (MHC) شامل گروهی از ژنها است که نقش مهمی در پاسخهای ایمنی دارند. اگزون 2 از ژن BuLA-DRB3 بخشی از MHC کلاس 2 در گاومیش است که تنوع بسیار بالایی داشته و آللهای آن با مقاومت/حساسیت به بیماریها و همچنین با خصوصیات تولیدی مرتبط هستند. هدف: شناسایی تنوع ژن BuLA-DRB3 در گاومیشهای خوزستان و مقایسه آن با سایر جمعیتهای گاومیش ایران و جهان. روش کار: نمونههای ...
The HLA-DR molecule is a polymorphic membrane glycoprotein and one of the key molecules causing allograft rejection and graft-versus-host disease in organ transplantation. Serologic typing using DR specific alloantisera has long been used, but several problems have limited its application. The purpose of this study was to establish an efficient reverse-SSO typing system that detects DRB1 and DR...
The discovery of novel antigens is an essential requirement in devising new diagnostics or vaccines for use in control programmes against human tuberculosis (TB) and bovine tuberculosis (bTB). Identification of potential epitopes recognised by CD4+ T cells requires prediction of peptide binding to MHC class-II, an obligatory prerequisite for T cell recognition. To comprehensively prioritise pot...
A single mismatch in highly expressed HLA-A, -B, -C, and -DRB1 loci (HEL) is associated with worse outcomes in hematopoietic stem cell transplantation, while less is known about the cumulative impact of mismatches in the lesser expressed HLA loci DRB3/4/5, DQ, and DP (LEL). We studied whether accumulation of LEL mismatches is associated with deleterious effects in 3853 unrelated donor transplan...
بز سرخ جبال بارز با جمعیتی بالغ بر 450 هزار رأس در منطقه جیرفت و کهنوج پرورش می یابد و با تولید کرک، گوشت قرمز و محصولات لبنی از منابع درآمد مهم عشایر و دامداران محسوب می شود. در این پژوهش که به منظور بررسی چند شکلی ژن gola-drb3 با استفاده از pcr-reflp در این دام ها صورت گرفت از 100 بز به صورت تصادفی و انفرادی خونگیری شد. سپس dna نمونه های خون دامها با استفاده از کیت استاندارد استخراج و تعیین ...
The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their similar functions and chromosomal positions. We examined variants in all functional HLA-DR beta genes in RA and SLE patients and controls, down t...
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