objective(s):  the aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin a.  material and methods:   formulations were designed based on full factorial design. a high pressure homogenization technique was used to produce nanosuspensions. fifteen formulations were prepared by the use of different combinations of surfa...

Correspondence : Michiru Genno, Technical Research Laboratory, Kurabo Industries Ltd., 14-5 Shimokidacho Neyagawa-shi, Osaka 572-0823, Japan. Tel.: +(81) 720 23 8800, Fax: +(81) 720 23 7906, E-mail: [email protected]

Objective(s):  The aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin A.  Material and Methods:   Formulations were designed based on full factorial design. A high pressure homogenization technique was used to produce nanosuspensions. Fifteen formulations were prepared by the use of different combinations of surfa...

Sodium and Ammonium Lauryl Sulfate are anionic surfactants used in cosmetics as cleansing agents. In absorption, metabolism, and excretion studies, Sodium Lauryl Sulfate had a degenerative effect on the cell membranes because of its protein denaturing properties. Low levels of skin penetration may occur at high use concentration. Sodium Lauryl Sulfate had an LD50 of 0.8 to 1.10 g/kg in rats. A ...

Background Glaucoma is a serious eye disease that can lead to loss of vision. Unfortunately, effective treatments are limited by poor bioavailability of antiglaucoma medicine due to short residence time on the preocular surface. Materials and methods To solve this, we successfully prepared novel controlled-release ion-exchange microparticles to deliver betaxolol hydrochloride (BH). Montmorill...

OBJECTIVE To describe the effects of long-term treatment with four different eye ointment bases (OBs) in cats. ANIMALS STUDIED Ten healthy cats. PROCEDURES The study was performed in two periods. Four different OBs were tested. Hundred grams of OB contained the following: OB-A: 35.17 g liquid paraffin (lp), 64.83 g white petrolatum (wp); OB-B: 10.03 g lp, 84.95 g wp 5.02 g lanolin; OB-C: 18...

BACKGROUND The traditional use of the oleo-gum-resin of Commiphora guidottii Chiov. ex. Guid., which is commonly called scented myrrh, for topical treatment of wound is well documented. The major objective of the present study was to investigate the essential oil and resin obtained from C. guidottii for their potential wound healing properties. Due to their influence on the wound healing proces...