Lymphocytic choriomeningitis virus (LCMV) causes a systemic infection in mice with virus replication occurring in both peripheral tissues and secondary lymphoid organs. Because of the rapid systemic dissemination of the virus, the secondary lymphoid organs responsible for the induction of the LCMV-specific CD8 T cell response are poorly defined. We show that the mediastinal lymph node (MedLN) s...

A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO+ pDCs directly activate resting CD4+CD25+Foxp3+ Tregs for potent suppressor activity. In vivo, Tregs isolated from tumor-draining LNs were constitutively activated and suppressed antigen-specific T cells immediately ex vivo. ...

This work was presented in part at the 40th annual meeting of American Diabetes Association, Washington, D. C., June 1979. Diabetes. 29: 8A. (Abstr.) Receivedfor publication 2July 1980 and in revisedform 22 September 1980. 292 lymnphocytotoxicity (CML) assays revealed increases in CML before graft rejection in low MLC reactors, and decreases in both CML and MLC responses before graft rejection ...

Extra oral sinus of odontogenic origin occurs when the purulent by-products of dental pulp necrosis spread along the path of least resistance from the root apex to the skin on the face. Patients presenting with cutaneous sinus usually visit a general physician or dermatologist first, as the lesion can mimic various dermatologic pathologies, ranging from an infected sebaceous cysts to a basal ce...

In the Rouse and Zimm models, polymer dynamics are simulated by approximating the polymer by N beads which are connected to their nearest neighbours by harmonic springs. In the “free-draining” Rouse model, each bead experiences solvent friction independent of the motion of the other beads, whereas the more realistic “non-draining” Zimm model also allows for hydrodynamic interactions between the...

Here we are reporting echocardiographic findings of 8 month child with Total Anomalous Pulmonary Venous Connection (TAPVC). All pulmonary veins are draining into a venous chamber (venous confluence) posterior to Left Atrium (LA). This chamber is draining in to persistent left superior vena cava (supradiaphragmatic type) with moderate (TR) and estimated (RV) systolic pressure was 88.2 mm of Hg s...

here, we report on a ten-year-old girl with chronic draining nonhealing ulcer in her neck and unilateral cervical chronic lymphadenopathy. her ulcer had poor clinical response to broad spectrum antibiotics and anti-tuberculosis treatment. she had undergone several wound biopsies with no conclusive results. she was otherwise healthy with no known underlying disease. final wound excisional biopsy...

We performed preliminary tests of the feasibility of multi-detector computed tomographic lymphography (MDCT-LG) with interstitial injection of iopamidol for mapping cutaneous lymphatic drainage pathways. MDCT-LG images were obtained following cutaneous injection of a total of 1ml iopamidol bilaterally into hind legs of 10 dogs. The locations of the first draining lymph nodes were marked on the ...

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